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Tbio
MLXIP
MLX-interacting protein

Protein Summary
Description
Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319080
  • ENSP00000312834
  • ENSG00000175727
  • ENST00000377037
  • ENSP00000366236
  • ENST00000538698
  • ENSP00000440769
  • ENST00000625732
  • ENSP00000486569
  • ENSG00000281178
  • ENST00000628109
  • ENSP00000486016
  • ENST00000629738
  • ENSP00000487003

Symbol
  • BHLHE36
  • KIAA0867
  • MIR
  • MONDOA
  • MIR
  • MONDOA
  • bHLHe36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
microRNA
0.7
disease perturbation
0.62
transcription factor perturbation
0.61
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.69   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.69   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (37)
1 – 10 of 37
MLX
Tchem
Family:  TF
Novelty:  0.0059946
p_int:  1
Score:  0.96
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.999999009
p_ni:  7.87e-7
p_wrong:  2.04e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
TXNIP
Tbio
Novelty:  0.00216952
Score:  0.855
Data Source:  STRINGDB
OGT
Tchem
Family:  Enzyme
Novelty:  0.00290822
Score:  0.853
Data Source:  STRINGDB
MLXIPL
Tbio
Family:  TF
Novelty:  0.00357389
Score:  0.818
Data Source:  STRINGDB
PPARGC1B
Tbio
Novelty:  0.01004477
Score:  0.804
Data Source:  STRINGDB
ARRDC4
Tbio
Novelty:  0.1036972
Score:  0.777
Data Source:  STRINGDB
MXD4
Tbio
Family:  TF
Novelty:  0.04724453
Score:  0.77
Data Source:  STRINGDB
MXD1
Tbio
Family:  TF
Novelty:  0.0353468
Score:  0.693
Data Source:  STRINGDB
MXD3
Tbio
Family:  TF
Novelty:  0.07436584
Score:  0.672
Data Source:  STRINGDB
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
10
10
91.2
waist-hip ratio
1
10
10
90.9
urate measurement
5
4
5
90.8
mean platelet volume
1
1
1
88
BMI-adjusted hip circumference
2
11
12
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
10
91.2
waist-hip ratio
10
90.9
urate measurement
5
90.8
mean platelet volume
1
88
BMI-adjusted hip circumference
12
87.3
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MLX interacting protein
VGNC:51261
452323
Macaque
MLX interacting protein
705874
Mouse
MGI:2141183
208104
Rat
RGD:1560774
304479
Dog
MLX interacting protein
VGNC:43268
477464
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MLX interacting protein
Macaque
MLX interacting protein
Mouse
Rat
Dog
MLX interacting protein
Publication Statistics
PubMed Score 27.69
PubMed score by year
PubTator Score 150.04
PubTator score by year