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Tbio
SAP30L
Histone deacetylase complex subunit SAP30L

Protein Summary
Description
Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). Isoform 2: Functions as transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Isoform 3: Functions as transcription repressor; its activity is marginally lower than that of isoform 1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297109
  • ENSP00000297109
  • ENSG00000164576
  • ENST00000426761
  • ENSP00000416393
  • ENST00000440364
  • ENSP00000390927

Symbol
  • NS4ATP2
  • NS4ATP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.87
histone modification site profile
0.75
gene perturbation
0.68
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.1   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.1   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0