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Tbio
MEAF6
Chromatin modification-related protein MEAF6

Protein Summary
Description
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296214
  • ENSP00000296214
  • ENSG00000163875
  • ENST00000373073
  • ENSP00000362164
  • ENST00000373075
  • ENSP00000362166
  • ENST00000448519
  • ENSP00000394966

Symbol
  • C1orf149
  • CENP-28
  • EAF6
  • EAF6
  • CENP-28
  • C1orf149
  • NY-SAR-91
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cellular component
0.78
cell type or tissue
0.69
transcription factor binding site profile
0.69
hub protein
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.55   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
MYST/Esa1 associated factor 6
713666
Mouse
MGI:1917338
70088
Rat
RGD:1310440
362594
Dog
MYST/Esa1 associated factor 6
VGNC:43113
475330
Horse
MYST/Esa1 associated factor 6
VGNC:20064
100069157
Species
Name
OMA
EggNOG
Inparanoid
Macaque
MYST/Esa1 associated factor 6
Mouse
Rat
Dog
MYST/Esa1 associated factor 6
Horse
MYST/Esa1 associated factor 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HAF1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Gene Ontology Terms (15)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (132)
1 – 10 of 132
KAT5
Tchem
Family: Epigenetic
Novelty: 0.00368348
p_int: 1
Score: 0.996
Data Source: BioPlex,STRINGDB
KAT7
Tbio
Family: TF; Epigenetic
Novelty: 0.01783137
p_int: 1
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
JADE2
Tbio
Family: Epigenetic
Novelty: 0.19820849
p_int: 1
Score: 0.989
Data Source: BioPlex,STRINGDB
JADE3
Tbio
Family: Epigenetic
Novelty: 0.29964429
p_int: 0.999999997
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.992
Data Source: BioPlex,STRINGDB
ING4
Tbio
Family: Epigenetic
Novelty: 0.01372992
p_int: 0.999999987
p_ni: 1e-8
p_wrong: 3e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
JADE1
Tbio
Family: Epigenetic
Novelty: 0.06758769
p_int: 0.999999983
p_ni: 1.1e-8
p_wrong: 6e-9
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
ING5
Tbio
Family: Epigenetic
Novelty: 0.03585867
p_int: 0.999999967
p_ni: 3.1e-8
p_wrong: 2e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
BRPF3
Tchem
Family: Epigenetic
Novelty: 0.14559787
p_int: 0.99999996
p_ni: 3.4e-8
p_wrong: 5e-9
Score: 0.995
Data Source: BioPlex,STRINGDB
KAT6B
Tbio
Family: Epigenetic
Novelty: 0.00361345
p_int: 0.9999998
p_ni: 1e-9
p_wrong: 1.99e-7
Score: 0.984
Data Source: BioPlex,Reactome,STRINGDB
BRPF1
Tchem
Family: Epigenetic
Novelty: 0.02524021
p_int: 0.999999772
p_ni: 2.25e-7
p_wrong: 3e-9
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  8.55

PubMed score by year
PubTator Score  4.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer