You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
WDR41
WD repeat-containing protein 41

Protein Summary
Description
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity (PubMed:27103069, PubMed:27617292).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296679
  • ENSP00000296679
  • ENSG00000164253
  • ENST00000507029
  • ENSP00000424287

Symbol
  • MSTP048
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
protein domain
0.73
tissue sample
0.69
transcription factor perturbation
0.68
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.19   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.19   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
45
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
45
Gene Ontology Terms (5)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (51)
1 – 10 of 51
C9orf72
Tbio
Novelty: 0.00096553
p_int: 0.999999788
p_ni: 2.12e-7
Score: 0.946
Data Source: BioPlex,STRINGDB
DNAJC7
Tbio
Novelty: 0.02133191
p_int: 0.99948209
p_ni: 0.000475309
p_wrong: 0.000042601
Data Source: BioPlex
SLC27A6
Tbio
Family: Transporter
Novelty: 0.01120087
p_int: 0.999205976
p_ni: 0.000773728
p_wrong: 0.000020296
Score: 0.187
Data Source: BioPlex,STRINGDB
APBB2
Tbio
Novelty: 0.06546724
p_int: 0.999010845
p_ni: 0.000895245
p_wrong: 0.000093911
Score: 0.198
Data Source: BioPlex,STRINGDB
MRAP2
Tbio
Novelty: 0.0420503
p_int: 0.998390303
p_ni: 0.001543891
p_wrong: 0.000065806
Data Source: BioPlex
TSPAN5
Tbio
Novelty: 0.08879443
p_int: 0.998310163
p_ni: 0.001639507
p_wrong: 0.00005033
Data Source: BioPlex
TKT
Tchem
Family: Enzyme
Novelty: 0.00333936
p_int: 0.942648567
p_ni: 0.001017734
p_wrong: 0.056333699
Score: 0.185
Data Source: BioPlex,STRINGDB
FBXO10
Tbio
Novelty: 0.18324932
p_int: 0.785223594
p_ni: 0.019113398
p_wrong: 0.195663008
Data Source: BioPlex
SMCR8
Tbio
Novelty: 0.11500348
Score: 0.981
Data Source: STRINGDB
RAB39B
Tbio
Family: Enzyme
Novelty: 0.02362498
Score: 0.823
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.19

PubMed score by year
PubTator Score  1.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer