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Tdark
UBTD1
Ubiquitin domain-containing protein 1

Protein Summary
Description
May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2. The degradation of many proteins is carried out by the ubiquitin pathway in which proteins are targeted for degradation by covalent conjugation of the polypeptide ubiquitin. This gene encodes a protein that belongs to the ubiquitin family of proteins. The encoded protein is thought to regulate E2 ubiquitin conjugating enzymes belonging to the UBE2D family. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370664
  • ENSP00000359698
  • ENSG00000165886
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
transcription factor
0.76
histone modification site profile
0.7
small molecule perturbation
0.64
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (21)
1 – 10 of 21
GJB7
Tdark
Novelty: 0.28301887
p_int: 0.99999994
p_wrong: 6e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
ANKRD13D
Tdark
p_int: 0.999944203
p_ni: 0.00005505
p_wrong: 7.47e-7
Data Source: BioPlex
VPS13C
Tbio
Novelty: 0.09280821
p_int: 0.999807776
p_ni: 0.000192224
Data Source: BioPlex
ATG2A
Tbio
Novelty: 0.10783517
p_int: 0.999666857
p_ni: 0.000012825
p_wrong: 0.000320318
Data Source: BioPlex
ANKRD13A
Tbio
Novelty: 0.42857143
p_int: 0.992389388
p_ni: 0.007610612
Data Source: BioPlex
NMT1
Tchem
Family: Enzyme
Novelty: 0.00436862
p_int: 0.970019294
p_ni: 0.029980706
Data Source: BioPlex
UBE2D2
Tbio
Novelty: 0.00827182
p_int: 0.879113489
p_ni: 0.000074762
p_wrong: 0.120811749
Score: 0.692
Data Source: BioPlex,STRINGDB
KIAA2026
Tdark
Family: Epigenetic
Novelty: 1.63636364
Score: 0.861
Data Source: STRINGDB
TMEM222
Tdark
Score: 0.815
Data Source: STRINGDB
MID1
Tbio
Family: Enzyme
Novelty: 0.02142845
Score: 0.752
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.74

PubMed score by year
PubTator Score  1.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer