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Tbio
SUGCT
Succinate--hydroxymethylglutarate CoA-transferase

Protein Summary
Description
Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3-hydroxymethylglutarate. This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335693
  • ENSP00000338475
  • ENSG00000175600
  • ENST00000401647
  • ENSP00000385222
  • ENST00000628514
  • ENSP00000486291

Symbol
  • C7orf10
  • DERP13
  • GA3
  • ORF19
  • DERP13
  • C7orf10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
gene perturbation
0.7
transcription factor
0.66
tissue sample
0.62
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.35   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.35   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
81.2
testosterone measurement
4
2
4
69.6
viral load
1
1
1
68.3
1
1
0
1.1
59.8
synophrys measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
81.2
testosterone measurement
4
69.6
viral load
1
68.3
0
1.1
59.8
synophrys measurement
1
40.7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HAC7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (67)
1 – 10 of 67
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.999943892
p_ni:  0.000041608
p_wrong:  0.0000145
Score:  0.173
Data Source:  BioPlex,STRINGDB
FOXRED1
Tbio
Family:  Enzyme
Novelty:  0.07057772
p_int:  0.999559835
p_ni:  0.000352958
p_wrong:  0.000087207
Score:  0.238
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.99814545
p_ni:  0.00126445
p_wrong:  0.0005901
Data Source:  BioPlex
MPLKIP
Tbio
Family:  Enzyme
Novelty:  0.01661924
Score:  0.906
Data Source:  STRINGDB
ETFA
Tbio
Novelty:  0.00193499
Score:  0.853
Data Source:  STRINGDB
GCDH
Tbio
Family:  Enzyme
Novelty:  0.0041805
Score:  0.732
Data Source:  STRINGDB
GGT2
Tbio
Family:  Enzyme
Novelty:  0.00399971
Score:  0.71
Data Source:  STRINGDB
GGTLC3
Tdark
Family:  Enzyme
Novelty:  0.00416359
Score:  0.71
Data Source:  STRINGDB
TAAR9
Tbio
Family:  GPCR
Novelty:  0.0059924
Score:  0.701
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.691
Data Source:  STRINGDB
Publication Statistics
PubMed Score  138.35

PubMed score by year
PubTator Score  280.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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