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Tbio
PPCS
Phosphopantothenate--cysteine ligase

Protein Summary
Description
Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372561
  • ENSP00000361642
  • ENSG00000127125
  • ENST00000372562
  • ENSP00000361643

Symbol
  • COAB
  • CMD2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
virus perturbation
0.79
transcription factor binding site profile
0.73
kinase perturbation
0.71
cellular component
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.76   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.76   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
p_int:  0.999941871
p_ni:  0.000058127
p_wrong:  2e-9
Data Source:  BioPlex
GXYLT2
Tdark
Family:  Enzyme
Novelty:  0.43960075
p_int:  0.99991692
p_ni:  0.00008308
Data Source:  BioPlex
C5orf46
Tdark
Novelty:  0.21780536
p_int:  0.925220731
p_ni:  1.27e-7
p_wrong:  0.074779143
Score:  0.692
Data Source:  BioPlex,STRINGDB
PPCDC
Tbio
Family:  Enzyme
Novelty:  0.0322534
Score:  0.997
Data Source:  STRINGDB
PANK1
Tbio
Family:  Kinase
Novelty:  0.00870107
Score:  0.977
Data Source:  STRINGDB
COASY
Tbio
Family:  Enzyme
Novelty:  0.00294867
Score:  0.972
Data Source:  STRINGDB
PANK4
Tbio
Family:  Kinase
Novelty:  0.14150809
Score:  0.969
Data Source:  STRINGDB
PANK2
Tbio
Family:  Kinase
Novelty:  0.00465551
Score:  0.961
Data Source:  STRINGDB
PANK3
Tchem
Family:  Kinase
Novelty:  0.06969329
Score:  0.957
Data Source:  STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
Score:  0.895
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Coenzyme A biosynthesis (R-HSA-196783)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Coenzyme A biosynthesis
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B5 (pantothenate) metabolism
Name
Explore in Pharos
Explore in Source
Coenzyme A biosynthesis
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B5 (pantothenate) metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
72.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
72.8
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphopantothenoylcysteine synthetase
697064
Mouse
MGI:1915237
106564
Rat
RGD:1311399
298490
Dog
phosphopantothenoylcysteine synthetase
VGNC:44841
475309
Horse
phosphopantothenoylcysteine synthetase
VGNC:21721
100067429
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphopantothenoylcysteine synthetase
Mouse
Rat
Dog
phosphopantothenoylcysteine synthetase
Horse
phosphopantothenoylcysteine synthetase
Publication Statistics
PubMed Score 77.76
PubMed score by year
PubTator Score 3.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title