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Tbio
CERS4
Ceramide synthase 4

Protein Summary
Description
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251363
  • ENSP00000251363
  • ENSG00000090661
  • ENST00000559450
  • ENSP00000453509

Symbol
  • LASS4
  • Trh1
  • LASS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.66
histone modification site profile
0.62
tissue sample
0.62
protein domain
0.58
tissue
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.23   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.23   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sphingolipid measurement
3
2
4
96.8
very long-chain saturated fatty acid measurement
3
2
0
10
93.8
blood metabolite measurement
1
1
2
82.9
sphingomyelin measurement
1
2
3
75.7
1
4
7
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sphingolipid measurement
4
96.8
very long-chain saturated fatty acid measurement
0
10
93.8
blood metabolite measurement
2
82.9
sphingomyelin measurement
3
75.7
7
75.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ceramide synthase 4
VGNC:2576
456435
Macaque
ceramide synthase 4
706728
Mouse
MGI:1914510
67260
Rat
RGD:1309303
304208
Dog
ceramide synthase 4
VGNC:39150
485008
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ceramide synthase 4
Macaque
ceramide synthase 4
Mouse
Rat
Dog
ceramide synthase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HA82-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (49)
1 – 10 of 49
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.999983307
p_ni: 0.000016679
p_wrong: 1.3e-8
Score: 0.563
Data Source: BioPlex,STRINGDB
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.999674818
p_ni: 0.000017945
p_wrong: 0.000307237
Score: 0.511
Data Source: BioPlex,STRINGDB
CERK
Tchem
Family: Kinase
Novelty: 0.0103948
Score: 0.96
Data Source: STRINGDB
UGCG
Tclin
Family: Enzyme
Novelty: 0.00481791
Score: 0.958
Data Source: STRINGDB
KDSR
Tbio
Family: Enzyme
Novelty: 0.0408411
Score: 0.953
Data Source: STRINGDB
UGT8
Tbio
Family: Enzyme
Novelty: 0.02518383
Score: 0.928
Data Source: STRINGDB
GALC
Tbio
Family: Enzyme
Novelty: 0.00203532
Score: 0.91
Data Source: STRINGDB
SGPP1
Tbio
Family: Enzyme
Novelty: 0.0514048
Score: 0.897
Data Source: STRINGDB
SPHK1
Tchem
Family: Kinase
Novelty: 0.00147889
Score: 0.875
Data Source: STRINGDB
SMPD2
Tchem
Family: Enzyme
Novelty: 0.00375744
Score: 0.873
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.23

PubMed score by year
PubTator Score  21.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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