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Tbio
CARS2
Probable cysteine--tRNA ligase, mitochondrial

Protein Summary
Description
This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257347
  • ENSP00000257347
  • ENSG00000134905

Symbol
  • cysRS
  • COXPD27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
transcription factor perturbation
0.91
protein domain
0.58
histone modification site profile
0.57
transcription factor binding site profile
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.89   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.89   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
1
1
56.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
1
56.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cysteinyl-tRNA synthetase 2, mitochondrial
694840
Mouse
MGI:1919191
71941
Rat
RGD:1311612
361184
Dog
cysteinyl-tRNA synthetase 2, mitochondrial
VGNC:49111
476983
Horse
cysteinyl-tRNA synthetase 2, mitochondrial
VGNC:50456
100066375
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cysteinyl-tRNA synthetase 2, mitochondrial
Mouse
Rat
Dog
cysteinyl-tRNA synthetase 2, mitochondrial
Horse
cysteinyl-tRNA synthetase 2, mitochondrial
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HA77-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
LYPD2
Tdark
Novelty: 0.55307434
p_int: 0.999999897
p_ni: 1.03e-7
Data Source: BioPlex
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.999999606
p_ni: 3.82e-7
p_wrong: 1.3e-8
Data Source: BioPlex
TCEAL9
Tdark
Novelty: 0.3050647
p_int: 0.999986099
p_ni: 0.00001381
p_wrong: 9.1e-8
Data Source: BioPlex
RGCC
Tbio
Novelty: 0.02696671
p_int: 0.999724253
p_ni: 0.000004955
p_wrong: 0.000270793
Score: 0.513
Data Source: BioPlex,STRINGDB
OXLD1
Tdark
Family: Enzyme
Novelty: 23
p_int: 0.999715852
p_ni: 0.000003895
p_wrong: 0.000280253
Score: 0.571
Data Source: BioPlex,STRINGDB
TRMT61B
Tbio
Family: Enzyme
Novelty: 0.32929047
p_int: 0.998691883
p_ni: 0.000001959
p_wrong: 0.001306158
Score: 0.755
Data Source: BioPlex,STRINGDB
YARS
Tchem
Family: Enzyme
Novelty: 0.00302115
Score: 0.981
Data Source: STRINGDB
EPRS
Tchem
Family: Enzyme
Novelty: 0.00084896
Score: 0.968
Data Source: STRINGDB
IARS
Tchem
Family: Enzyme
Novelty: 0.00539046
Score: 0.942
Data Source: STRINGDB
IARS2
Tbio
Family: Enzyme
Novelty: 0.00854621
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  92.89

PubMed score by year
PubTator Score  16.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer