Tbio CALHM2 Calcium homeostasis modulator protein 2

Protein Summary

Description

Pore-forming subunit of a voltage-gated ion channel.

Uniprot Accession IDs

• Q9HA72
• D3DR94
• O95893
• Q6ZUV9

Gene Name

• CALHM2

Ensembl ID

• ENST00000260743
• ENSP00000260743
• ENSG00000138172
• ENST00000369788
• ENSP00000358803

Symbol

• FAM26B
• FAM26B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.61
tissue sample	0.6
cell type or tissue	0.58
histone modification site profile	0.49
gene perturbation	0.46

Protein Classes

DTO Classes

Protein / Ion Channel / Calcium Homeostasis Modulator Calcium Channel (Calhm-c) Family / Calcium Homeostasis Modulator Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 16   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.68   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0