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Tbio
FN3KRP
Ketosamine-3-kinase

Protein Summary
Description
Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein-bound psicosamine 3-phosphates and ribulosamine 3-phosphates are unstable and decompose under physiological conditions. Thus phosphorylation leads to deglycation. A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269373
  • ENSP00000269373
  • ENSG00000141560

Symbol
  • FN3KL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
kinase perturbation
0.71
cell type or tissue
0.69
tissue
0.57
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
LTF
Tbio
Novelty:  0.00114254
p_int:  0.97039602
p_ni:  0.02960398
Score:  0.235
Data Source:  BioPlex,STRINGDB
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.965092267
p_ni:  0.034907733
Score:  0.211
Data Source:  BioPlex,STRINGDB
DOHH
Tbio
Family:  Enzyme
Novelty:  0.02313651
p_int:  0.897311622
p_ni:  0.102688378
Score:  0.288
Data Source:  BioPlex,STRINGDB
IGHA1
Tbio
p_int:  0.818054172
p_ni:  0.181945828
Data Source:  BioPlex
B3GNTL1
Tdark
Family:  Enzyme
Novelty:  0.13396783
Score:  0.779
Data Source:  STRINGDB
ZNF750
Tbio
Novelty:  0.05236342
Score:  0.753
Data Source:  STRINGDB
CASC1
Tdark
Novelty:  0.07508229
Score:  0.743
Data Source:  STRINGDB
URB1
Tbio
Novelty:  0.04246076
Score:  0.714
Data Source:  STRINGDB
TBCD
Tbio
Novelty:  0.01161221
Score:  0.675
Data Source:  STRINGDB
RIOK2
Tbio
Family:  Kinase
Novelty:  0.02940435
Score:  0.654
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Gamma carboxylation, hypusine formation and arylsulfatase activation (R-HSA-163841)

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1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gamma carboxylation, hypusine formation and arylsulfatase activation
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gamma carboxylation, hypusine formation and arylsulfatase activation
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
13
16
21
99.6
red blood cell distribution width
1
1
1
58.4
mean platelet volume
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
21
99.6
red blood cell distribution width
1
58.4
mean platelet volume
1
38.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fructosamine 3 kinase related protein
VGNC:9285
107969011
Macaque
fructosamine 3 kinase related protein
716431
Mouse
MGI:2679256
238024
Rat
RGD:1304570
303755
Dog
fructosamine 3 kinase related protein
VGNC:40923
480821
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fructosamine 3 kinase related protein
Macaque
fructosamine 3 kinase related protein
Mouse
Rat
Dog
fructosamine 3 kinase related protein
Publication Statistics
PubMed Score 9.39
PubMed score by year
PubTator Score 9.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title