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Tbio
UCK1
Uridine-cytidine kinase 1

Protein Summary
Description
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine. This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372208
  • ENSP00000361282
  • ENSG00000130717
  • ENST00000372210
  • ENSP00000361284
  • ENST00000372211
  • ENSP00000361285
  • ENST00000372215
  • ENSP00000361289

Symbol
  • URK1
  • URK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
tissue sample
0.7
biological process
0.67
histone modification site profile
0.66
tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.518
Data Source:  BioPlex,STRINGDB
UPRT
Tbio
Family:  Enzyme
Novelty:  0.00506163
p_int:  0.999999078
p_ni:  9.22e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
UCK2
Tbio
Family:  Kinase
Novelty:  0.02417595
p_int:  0.999997988
p_wrong:  0.000002012
Score:  0.97
Data Source:  BioPlex,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.999792265
p_ni:  0.000145404
p_wrong:  0.000062331
Score:  0.735
Data Source:  BioPlex,STRINGDB
UMPS
Tclin
Family:  Enzyme
Novelty:  0.00848756
Score:  0.974
Data Source:  STRINGDB
UPP1
Tchem
Family:  Enzyme
Novelty:  0.01384975
Score:  0.968
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.957
Data Source:  STRINGDB
UPP2
Tbio
Family:  Enzyme
Novelty:  0.03788751
Score:  0.954
Data Source:  STRINGDB
ENTPD3
Tbio
Family:  Enzyme
Novelty:  0.01673548
Score:  0.937
Data Source:  STRINGDB
ENTPD8
Tbio
Family:  Enzyme
Novelty:  0.00989166
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 4 of 4
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (13)
Metabolism (R-HSA-1430728)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Pyrimidine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Pyrimidine salvage
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
advanced glycosylation end product-specific receptor ligand measurement
1
1
1
80.5
smoking status measurement
2
1
2
55.2
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
advanced glycosylation end product-specific receptor ligand measurement
1
80.5
smoking status measurement
2
55.2
0
1.1
21.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
uridine-cytidine kinase 1
715417
Mouse
MGI:98904
22245
Rat
RGD:1308313
311864
Horse
uridine-cytidine kinase 1
VGNC:24762
100069565
Cow
uridine-cytidine kinase 1
VGNC:36634
519697
Species
Name
OMA
EggNOG
Inparanoid
Macaque
uridine-cytidine kinase 1
Mouse
Rat
Horse
uridine-cytidine kinase 1
Cow
uridine-cytidine kinase 1
Publication Statistics
PubMed Score 9.39
PubMed score by year
PubTator Score 10.50
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title