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Tbio
ZMAT3
Zinc finger matrin-type protein 3

Protein Summary
Description
Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus. This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311417
  • ENSP00000311221
  • ENSG00000172667
  • ENST00000432729
  • ENSP00000396506

Symbol
  • PAG608
  • WIG1
  • WIG1
  • WIG-1
  • PAG608
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
0.9
disease perturbation
0.83
transcription factor binding site profile
0.82
histone modification site profile
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.35   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.35   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
81.4
mean platelet volume
2
2
2
81.1
platelet count
1
1
1
48.7
mean corpuscular volume
1
1
1
34
platelet crit
1
1
1
31.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
81.4
mean platelet volume
2
81.1
platelet count
1
48.7
mean corpuscular volume
1
34
platelet crit
1
31.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger matrin-type 3
VGNC:12249
471005
Macaque
zinc finger matrin-type 3
710132
Mouse
MGI:1195270
22401
Rat
RGD:620134
64394
Dog
zinc finger matrin-type 3
VGNC:48640
100855542
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger matrin-type 3
Macaque
zinc finger matrin-type 3
Mouse
Rat
Dog
zinc finger matrin-type 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HA38-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (41)
1 – 10 of 41
DCAF17
Tbio
Novelty: 0.04261326
p_int: 0.999997332
p_ni: 2e-9
p_wrong: 0.000002666
Score: 0.269
Data Source: BioPlex,STRINGDB
ISCA1
Tbio
Novelty: 0.01288069
p_int: 0.947161389
p_ni: 0.048964234
p_wrong: 0.003874377
Score: 0.171
Data Source: BioPlex,STRINGDB
SUPV3L1
Tbio
Family: Enzyme
Novelty: 0.01598799
p_int: 0.944491948
p_ni: 0.05550776
p_wrong: 2.91e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
FTO
Tbio
Family: Enzyme
Novelty: 0.00053473
p_int: 0.937657355
p_ni: 0.062264787
p_wrong: 0.000077858
Score: 0.513
Data Source: BioPlex,STRINGDB
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.892820503
p_ni: 0.107179497
Score: 0.177
Data Source: BioPlex,STRINGDB
TARBP2
Tbio
Novelty: 0.01485994
p_int: 0.799660054
p_ni: 0.200339946
Score: 0.229
Data Source: BioPlex,STRINGDB
RIOK3
Tchem
Family: Kinase
Novelty: 0.07513953
Score: 0.72
Data Source: STRINGDB
PHLDA3
Tbio
Novelty: 0.07016635
Score: 0.679
Data Source: STRINGDB
PIGP
Tbio
Family: Enzyme
Novelty: 0.01400934
Score: 0.663
Data Source: STRINGDB
EI24
Tbio
Novelty: 0.02042684
Score: 0.647
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.35

PubMed score by year
PubTator Score  15.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer