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Tbio
LIN28A
Protein lin-28 homolog A

Protein Summary
Description
RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and rec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254231
  • ENSP00000254231
  • ENSG00000131914
  • ENST00000326279
  • ENSP00000363314

Symbol
  • CSDD1
  • LIN28
  • ZCCHC1
  • CSDD1
  • LIN28
  • LIN-28
  • ZCCHC1
  • lin-28A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.88
biological process
0.82
gene perturbation
0.78
transcription factor
0.73
biological term
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.77   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 674   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.77   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 674   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
1
2
93.5
body height
1
1
1
25.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
93.5
body height
1
25.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lin-28 homolog A
VGNC:11510
456661
Mouse
MGI:1890546
83557
Rat
RGD:1566408
500562
Dog
lin-28 homolog A
VGNC:42683
612162
Horse
lin-28 homolog A
VGNC:19673
100071098
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lin-28 homolog A
Mouse
Rat
Dog
lin-28 homolog A
Horse
lin-28 homolog A
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H9Z2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Transcriptional regulation of pluripotent stem cells
Gene Ontology Terms (34)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (158)
1 – 10 of 158
POU5F1
Tbio
Family: TF
Novelty: 0.00033974
Score: 0.996
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.994
Data Source: STRINGDB
NANOG
Tbio
Family: TF
Novelty: 0.00054893
Score: 0.994
Data Source: STRINGDB
KLF4
Tbio
Family: TF
Novelty: 0.00076828
Score: 0.989
Data Source: STRINGDB
SALL4
Tbio
Family: TF
Novelty: 0.00354374
Score: 0.976
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.965
Data Source: STRINGDB
PRDM14
Tbio
Family: TF; Epigenetic
Novelty: 0.01776592
Score: 0.957
Data Source: STRINGDB
ZSCAN10
Tdark
Family: TF
Novelty: 0.14279957
Score: 0.949
Data Source: STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.925
Data Source: STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  544.77

PubMed score by year
PubTator Score  263.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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