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Tbio
POLR1B
DNA-directed RNA polymerase I subunit RPA2

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 200 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263331
  • ENSP00000263331
  • ENSG00000125630
  • ENST00000409894
  • ENSP00000387143
  • ENST00000417433
  • ENSP00000405358
  • ENST00000537335
  • ENSP00000437914
  • ENST00000541869
  • ENSP00000444136

Symbol
  • RPA2
  • RPA135
  • Rpo1-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.83
transcription factor binding site profile
0.82
molecular function
0.73
protein complex
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
3
81.8
smoking initiation
1
1
1
44.2
smoking behaviour measurement
1
1
1
36.5
sex hormone-binding globulin measurement
1
1
1
35
smoking behavior
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
81.8
smoking initiation
1
44.2
smoking behaviour measurement
1
36.5
sex hormone-binding globulin measurement
1
35
smoking behavior
1
17.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I subunit B
VGNC:375
459495
Mouse
MGI:108014
20017
Rat
RGD:620822
83582
Dog
RNA polymerase I subunit B
VGNC:44789
100856298
Horse
RNA polymerase I subunit B
VGNC:21669
100052113
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase I subunit B
Mouse
Rat
Dog
RNA polymerase I subunit B
Horse
RNA polymerase I subunit B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H9Y6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (508)
1 – 10 of 508
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.998868603
p_ni:  0.001131397
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.982908202
p_ni:  0.017091798
Score:  0.999
Data Source:  BioPlex,STRINGDB
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.980341639
p_ni:  0.019658361
Data Source:  BioPlex
RRN3
Tbio
Family:  Enzyme
Novelty:  0.01643149
p_int:  0.966727736
p_ni:  0.033272264
Score:  0.997
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.957019691
p_ni:  0.042980309
Score:  0.729
Data Source:  BioPlex,STRINGDB
TWISTNB
Tdark
Family:  Enzyme
Novelty:  0.59160737
p_int:  0.904795977
p_ni:  0.095204023
Score:  0.999
Data Source:  BioPlex,STRINGDB
GPN1
Tbio
Family:  Enzyme
Novelty:  0.06883613
p_int:  0.8209702
p_ni:  0.1790298
Score:  0.388
Data Source:  BioPlex,STRINGDB
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
Score:  0.999
Data Source:  STRINGDB
POLR1E
Tbio
Family:  Enzyme
Novelty:  0.09991103
Score:  0.999
Data Source:  STRINGDB
POLR1D
Tbio
Novelty:  0.01598347
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.07

PubMed score by year
PubTator Score  0.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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