POLR1B
DNA-directed RNA polymerase I subunit RPA2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
disease perturbation | 0.83 | ||
transcription factor binding site profile | 0.82 | ||
molecular function | 0.73 | ||
protein complex | 0.7 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Reactome | Epigenetic regulation of gene expression | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Negative epigenetic regulation of rRNA expression | ||||
Reactome | NoRC negatively regulates rRNA expression | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
B-WICH complex positively regulates rRNA expression | ||||
Epigenetic regulation of gene expression | ||||
Gene expression (Transcription) | ||||
Negative epigenetic regulation of rRNA expression | ||||
NoRC negatively regulates rRNA expression | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 2 | 3 | 81.8 | |||||
smoking initiation | 1 | 1 | 1 | 44.2 | |||||
smoking behaviour measurement | 1 | 1 | 1 | 36.5 | |||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 35 | |||||
smoking behavior | 1 | 1 | 1 | 17.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
smoking status measurement | 3 | 81.8 | |||||
smoking initiation | 1 | 44.2 | |||||
smoking behaviour measurement | 1 | 36.5 | |||||
sex hormone-binding globulin measurement | 1 | 35 | |||||
smoking behavior | 1 | 17.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | RNA polymerase I subunit B | VGNC:375 | 459495 | |||||
Mouse | MGI:108014 | 20017 | ||||||
Rat | RGD:620822 | 83582 | ||||||
Dog | RNA polymerase I subunit B | VGNC:44789 | 100856298 | |||||
Horse | RNA polymerase I subunit B | VGNC:21669 | 100052113 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | RNA polymerase I subunit B | |||||
Mouse | ||||||
Rat | ||||||
Dog | RNA polymerase I subunit B | |||||
Horse | RNA polymerase I subunit B | |||||
PMID | Year | Title |
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