Tbio POLR1B DNA-directed RNA polymerase I subunit RPA2

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Dna-directed Rna Polymerase I Subunit Rpa2

Protein / Nucleic Acid Binding / Rna Binding Protein / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase I Subunit Rpa2

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Rna Polymerase / Dna-directed Rna Polymerase I Subunit Rpa2

Protein Summary

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9H9Y6
• B7Z6Y7
• B7Z823
• F5GZX4
• F8W898
• Q2TAM4
• Q585T5
• Q6ZRR2
• Q9H9D3
• RNA polymerase I subunit 2

Gene Name

• POLR1B

Ensembl ID

• ENST00000263331
• ENSP00000263331
• ENSG00000125630
• ENST00000409894
• ENSP00000387143
• ENST00000417433
• ENSP00000405358
• ENST00000537335
• ENSP00000437914
• ENST00000541869
• ENSP00000444136

Symbol

• RPA2
• RPA135
• Rpo1-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.83
transcription factor binding site profile	0.82
molecular function	0.73
protein complex	0.7

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (7)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking status measurement	EFO_0006527	2	2	3		81.8
smoking initiation	EFO_0005670	1	1	1		44.2
smoking behaviour measurement	EFO_0005671	1	1	1		36.5
sex hormone-binding globulin measurement	EFO_0004696	1	1	1		35
smoking behavior	EFO_0004318	1	1	1		17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
smoking status measurement	EFO_0006527	3		81.8
smoking initiation	EFO_0005670	1		44.2
smoking behaviour measurement	EFO_0005671	1		36.5
sex hormone-binding globulin measurement	EFO_0004696	1		35
smoking behavior	EFO_0004318	1		17.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RNA polymerase I subunit B	VGNC:375	459495
Mouse	polymerase (RNA) I polypeptide B	MGI:108014	20017
Rat	RNA polymerase I subunit B	RGD:620822	83582
Dog	RNA polymerase I subunit B	VGNC:44789	100856298
Horse	RNA polymerase I subunit B	VGNC:21669	100052113

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RNA polymerase I subunit B
Mouse	polymerase (RNA) I polypeptide B
Rat	RNA polymerase I subunit B
Dog	RNA polymerase I subunit B
Horse	RNA polymerase I subunit B

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9H9Y6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)

Reactome (11)

KEGG (1)

PathwayCommons (2)

WikiPathways (2)

B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

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Find Similar Targets

Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924
Reactome	Epigenetic regulation of gene expression	118 targets	R-HSA-212165
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Negative epigenetic regulation of rRNA expression	79 targets	R-HSA-5250941
Reactome	NoRC negatively regulates rRNA expression	76 targets	R-HSA-427413

Name	Explore in Pharos	Explore in Source
B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924
Epigenetic regulation of gene expression	118 targets	R-HSA-212165
Gene expression (Transcription)	1452 targets	R-HSA-74160
Negative epigenetic regulation of rRNA expression	79 targets	R-HSA-5250941
NoRC negatively regulates rRNA expression	76 targets	R-HSA-427413

Gene Ontology Terms (14)

Functions (4)

Components (4)

Processes (6)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
DNA binding	Inferred from Electronic Annotation (IEA)	InterPro
DNA-directed 5'-3' RNA polymerase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
ribonucleoside binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (508)

Explore Interacting Targets

1 – 10 of 508

• See Interactions on String-DB

POLR1C

Tbio

Family:  Enzyme

Novelty:  0.04485332

p_int:  0.998868603

p_ni:  0.001131397

Score:  0.999

Data Source:  BioPlex,STRINGDB

POLR2E

Tbio

Family:  Enzyme

Novelty:  0.01817288

p_int:  0.982908202

p_ni:  0.017091798

Score:  0.999

Data Source:  BioPlex,STRINGDB

SKAP1

Tbio

Family:  Enzyme

Novelty:  0.03753848

p_int:  0.980341639

p_ni:  0.019658361

Data Source:  BioPlex

RRN3

Tbio

Family:  Enzyme

Novelty:  0.01643149

p_int:  0.966727736

p_ni:  0.033272264

Score:  0.997

Data Source:  BioPlex,STRINGDB

GPN3

Tbio

Family:  Enzyme

Novelty:  0.13817794

p_int:  0.957019691

p_ni:  0.042980309

Score:  0.729

Data Source:  BioPlex,STRINGDB

TWISTNB

Tdark

Family:  Enzyme

Novelty:  0.59160737

p_int:  0.904795977

p_ni:  0.095204023

Score:  0.999

Data Source:  BioPlex,STRINGDB

GPN1

Tbio

Family:  Enzyme

Novelty:  0.06883613

p_int:  0.8209702

p_ni:  0.1790298

Score:  0.388

Data Source:  BioPlex,STRINGDB

POLR2L

Tbio

Family:  Enzyme

Novelty:  0.03847579

Score:  0.999

Data Source:  STRINGDB

POLR1E

Tbio

Family:  Enzyme

Novelty:  0.09991103

Score:  0.999

Data Source:  STRINGDB

POLR1D

Tbio

Novelty:  0.01598347

Score:  0.999

Data Source:  STRINGDB

Publication Statistics

PubMed Score  14.07

PubMed score by year

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PubTator Score  0.38

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
DNA-directed RNA polymerase
Metal-binding
Nucleotidyltransferase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transcription

GWAS Trait Find Similar Targets

No Header	No Header
alcohol consumption measurement
C-reactive protein measurement
sex hormone-binding globulin measurement
smoking behavior
smoking behaviour measurement
smoking initiation
smoking status measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
mortality/aging