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Tdark
GPN2
GPN-loop GTPase 2

Protein Summary
Description
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374135
  • ENSP00000363250
  • ENSG00000142751

Symbol
  • ATPBD1B
  • ATPBD1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.81
molecular function
0.79
transcription factor binding site profile
0.65
tissue sample
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.88   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.88   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GPN-loop GTPase 2
VGNC:8338
737565
Macaque
GPN-loop GTPase 2
714995
Mouse
MGI:2140368
100210
Rat
RGD:1311749
362614
Dog
GPN-loop GTPase 2
VGNC:41387
610227
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GPN-loop GTPase 2
Macaque
GPN-loop GTPase 2
Mouse
Rat
Dog
GPN-loop GTPase 2
Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (38)
1 – 10 of 38
POLR2M
Tbio
Family: Enzyme
Novelty: 0.11413088
p_int: 0.999790437
p_ni: 0.00005189
p_wrong: 0.000157673
Score: 0.821
Data Source: BioPlex,STRINGDB
POLR2J
Tbio
Family: Enzyme
Novelty: 0.02344868
p_int: 0.999643802
p_ni: 0.00035617
p_wrong: 2.8e-8
Score: 0.803
Data Source: BioPlex,STRINGDB
RPAP1
Tdark
Family: Enzyme
Novelty: 0.23737405
p_int: 0.997693419
p_ni: 0.002306581
Score: 0.896
Data Source: BioPlex,STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.997654096
p_ni: 0.002345904
Score: 0.237
Data Source: BioPlex,STRINGDB
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.99700117
p_ni: 0.001262902
p_wrong: 0.001735928
Score: 0.273
Data Source: BioPlex,STRINGDB
GPN1
Tbio
Family: Enzyme
Novelty: 0.06883613
p_int: 0.994720277
p_ni: 0.005279723
p_wrong: 1e-9
Score: 0.974
Data Source: BioPlex,STRINGDB
POLR2L
Tbio
Family: Enzyme
Novelty: 0.03847579
p_int: 0.992551658
p_ni: 0.007448064
p_wrong: 2.79e-7
Score: 0.789
Data Source: BioPlex,STRINGDB
POLR2B
Tbio
Family: Enzyme
Novelty: 0.0012624
p_int: 0.799832419
p_ni: 0.200167581
Score: 0.882
Data Source: BioPlex,STRINGDB
POLR2M
Tbio
Family: Enzyme
Novelty: 0.11413088
Score: 0.821
Data Source: STRINGDB
NPHS1
Tbio
Novelty: 0.00104742
Score: 0.702
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.88

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer