Tbio ELP3 Elongator complex protein 3

Protein Summary

Description

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in acetylation of alpha-tubulin (PubMed:19185337). May also have a methyltransferase activity. Involved in cell migration. Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP3 is the catalytic subunit of the histone acetyltransferase elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons (Creppe et al., 2009 [PubMed 19185337]).[supplied by OMIM, Apr 2009]

Uniprot Accession IDs

• Q9H9T3
• B4DE19
• B4DIG1
• E2QRI5
• Q53G84
• Q6AWB0
• Q9BVF7
• Q9NVZ1
• hELP3

Gene Name

• ELP3

Ensembl ID

• ENST00000256398
• ENSP00000256398
• ENSG00000134014
• ENST00000380353
• ENSP00000369711
• ENST00000521015
• ENSP00000428449
• ENST00000537665
• ENSP00000445558

Symbol

• KAT9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
molecular function	0.95
disease perturbation	0.93
transcription factor perturbation	0.91
virus perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Elongator Complex Protein 3

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Elongator Complex Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.91   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.91   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0