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Tdark
SEC61A2
Protein transport protein Sec61 subunit alpha isoform 2

Protein Classes
Protein Summary
Description
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298428
  • ENSP00000298428
  • ENSG00000065665
  • ENST00000304267
  • ENSP00000302048
  • ENST00000379033
  • ENSP00000368319
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
histone modification site profile
0.91
transcription factor perturbation
0.68
small molecule perturbation
0.67
microRNA
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.41   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 3   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.41   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 3   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
13
5
4
1.1
97.6
forced expiratory volume
4
3
3
1.2
93.3
FEV/FEC ratio
1
1
1
86
peak expiratory flow
1
1
1
81.5
HbA1c measurement
3
2
3
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
97.6
forced expiratory volume
3
1.2
93.3
FEV/FEC ratio
1
86
peak expiratory flow
1
81.5
HbA1c measurement
3
78.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Sec61 translocon alpha 2 subunit
VGNC:7258
450305
Macaque
Sec61 translocon alpha 2 subunit
100427731
Mouse
MGI:1931071
57743
Rat
RGD:1305948
361273
Dog
Sec61 translocon alpha 2 subunit
VGNC:49615
478007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Sec61 translocon alpha 2 subunit
Macaque
Sec61 translocon alpha 2 subunit
Mouse
Rat
Dog
Sec61 translocon alpha 2 subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H9S3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ER-Phagosome pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
ER-Phagosome pathway
Immune System
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (293)
1 – 10 of 293
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.997
Data Source:  Reactome,STRINGDB
RPL9
Tbio
Novelty:  0.00845583
Score:  0.997
Data Source:  STRINGDB
RPS3
Tbio
Novelty:  0.003106
Score:  0.996
Data Source:  STRINGDB
RPL5
Tbio
Novelty:  0.00663792
Score:  0.995
Data Source:  STRINGDB
RPL23
Tbio
Novelty:  0.02741113
Score:  0.995
Data Source:  STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.995
Data Source:  STRINGDB
RPL26
Tbio
Novelty:  0.02077198
Score:  0.994
Data Source:  STRINGDB
RPS11
Tbio
Novelty:  0.0168881
Score:  0.994
Data Source:  STRINGDB
SEC61G
Tbio
Novelty:  0.11375671
Score:  0.994
Data Source:  Reactome,STRINGDB
RPS15
Tbio
Novelty:  0.00635155
Score:  0.994
Data Source:  STRINGDB
Publication Statistics
PubMed Score  0.41

PubMed score by year
PubTator Score  0.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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