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Tbio
NHEJ1
Non-homologous end-joining factor 1

Protein Summary
Description
DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:16439204, PubMed:16439205, PubMed:17470781). Binds DNA in a length-dependent manner (PubMed:17317666). Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356853
  • ENSP00000349313
  • ENSG00000187736
  • ENST00000409720
  • ENSP00000387290

Symbol
  • XLF
  • XLF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
histone modification site profile
0.86
transcription factor binding site profile
0.64
small molecule perturbation
0.6
transcription factor
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.62   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 393   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.62   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
3
4
96.1
sex hormone-binding globulin measurement
2
1
2
67.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
96.1
sex hormone-binding globulin measurement
2
67.6
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Nonhomologous End-Joining (NHEJ)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Nonhomologous End-Joining (NHEJ)
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (81)
1 – 10 of 81
XRCC4
Tbio
Novelty: 0.00305644
Score: 0.999
Data Source: Reactome,STRINGDB
XRCC5
Tbio
Novelty: 0.00150735
Score: 0.993
Data Source: Reactome,STRINGDB
PRKDC
Tchem
Family: Kinase
Novelty: 0.00107984
Score: 0.992
Data Source: Reactome,STRINGDB
LIG4
Tbio
Family: Enzyme
Novelty: 0.00412993
Score: 0.985
Data Source: Reactome,STRINGDB
XRCC6
Tbio
Novelty: 0.00127955
Score: 0.985
Data Source: Reactome,STRINGDB
PAXX
Tbio
Novelty: 0.03754932
Score: 0.978
Data Source: STRINGDB
DCLRE1C
Tbio
Novelty: 0.01064408
Score: 0.97
Data Source: Reactome,STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.966
Data Source: STRINGDB
POLL
Tbio
Family: Enzyme
Novelty: 0.00244645
Score: 0.949
Data Source: Reactome,STRINGDB
POLM
Tbio
Family: Enzyme
Novelty: 0.00362931
Score: 0.94
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  145.62

PubMed score by year
PubTator Score  35.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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