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Tbio
COPS7B
COP9 signalosome complex subunit 7b

Protein Summary
Description
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350033
  • ENSP00000272995
  • ENSG00000144524
  • ENST00000373608
  • ENSP00000362710
  • ENST00000409091
  • ENSP00000386527
  • ENST00000410024
  • ENSP00000386567
  • ENST00000620578
  • ENSP00000484579

Symbol
  • CSN7B
  • CSN7B
  • SGN7b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
disease perturbation
0.93
histone modification site profile
0.62
interacting protein
0.57
gene perturbation
0.56


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.38   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.38   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COP9 signalosome subunit 7B
VGNC:144
738357
Macaque
COP9 signalosome subunit 7B
712697
Mouse
MGI:1349388
26895
Rat
RGD:1306918
363273
Dog
COP9 signalosome subunit 7B
VGNC:39514
610156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COP9 signalosome subunit 7B
Macaque
COP9 signalosome subunit 7B
Mouse
Rat
Dog
COP9 signalosome subunit 7B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H9Q2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Formation of TC-NER Pre-Incision Complex
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
DNA Damage Recognition in GG-NER
DNA Repair
Formation of TC-NER Pre-Incision Complex
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (253)
1 – 10 of 253
COPS6
Tbio
Novelty: 0.02653008
p_int: 0.999999993
p_ni: 7e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
COPS5
Tbio
Novelty: 0.00406225
p_int: 0.99999996
p_ni: 4e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
COPS2
Tbio
Novelty: 0.03509351
p_int: 0.999999946
p_ni: 5.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
COPS3
Tbio
Novelty: 0.04664225
p_int: 0.999999932
p_ni: 6.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
COPS8
Tbio
Novelty: 0.0408885
p_int: 0.999999671
p_ni: 3.29e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
SUN2
Tbio
Novelty: 0.01387591
p_int: 0.999968221
p_ni: 0.000031779
Data Source: BioPlex
BTBD1
Tbio
Novelty: 0.19772296
p_int: 0.999966782
p_ni: 0.000033218
Score: 0.965
Data Source: BioPlex,STRINGDB
SPAG5
Tbio
Novelty: 0.02392116
p_int: 0.999934754
p_ni: 0.000065246
Data Source: BioPlex
DST
Tbio
Novelty: 0.00238839
p_int: 0.999916453
p_ni: 0.000083545
p_wrong: 2e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
APPBP2
Tbio
Novelty: 0.14742368
p_int: 0.999812419
p_ni: 0.000187581
Score: 0.216
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.38

PubMed score by year
PubTator Score  0.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer