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Tdark
UNKL
Putative E3 ubiquitin-protein ligase UNKL

Protein Summary
Description
May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other substrates, such as SMARCD2/BAF60b. Intrinsic E3 ligase activity has not been proven. This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248104
  • ENSP00000248104
  • ENSG00000059145
  • ENST00000301712
  • ENSP00000301712
  • ENST00000397464
  • ENSP00000380606

Symbol
  • C16orf28
  • ZC3H5L
  • ZC3HDC5L
  • ZC3H5L
  • C16orf28
  • ZC3HDC5L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
microRNA
0.69
cell line
0.64
kinase perturbation
0.6
transcription factor
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.59   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.59   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
1
1
0
50.6
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
inflammatory biomarker measurement
0
50.6
51.4
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921404
74154
Rat
RGD:1565247
302987
Dog
unkempt family like zinc finger
VGNC:54086
490077
Opossum
unkempt family like zinc finger
100010478
Xenopus
unkempt family like zinc finger
XB-GENE-1217319
100144682
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
unkempt family like zinc finger
Opossum
unkempt family like zinc finger
Xenopus
unkempt family like zinc finger
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Protein-Protein Interactions (285)
1 – 10 of 285
GGPS1
Tchem
Family: Enzyme
Novelty: 0.00292258
p_int: 0.92033807
p_ni: 0.079661891
p_wrong: 3.9e-8
Score: 0.199
Data Source: BioPlex,STRINGDB
TRPC4AP
Tbio
Novelty: 0.02170224
p_int: 0.913339964
p_ni: 0.007435744
p_wrong: 0.079224292
Score: 0.188
Data Source: BioPlex,STRINGDB
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.88882381
p_ni: 0.111176189
p_wrong: 1e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
SH3RF1
Tbio
Family: Enzyme
Novelty: 0.01836588
Score: 0.945
Data Source: STRINGDB
CUL2
Tbio
Novelty: 0.00512916
Score: 0.944
Data Source: STRINGDB
BTBD6
Tdark
Novelty: 0.24005804
Score: 0.941
Data Source: STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.03924839
Score: 0.916
Data Source: STRINGDB
DCAF1
Tbio
Novelty: 0.0170232
Score: 0.913
Data Source: STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.909
Data Source: STRINGDB
CUL5
Tbio
Novelty: 0.00792494
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.59

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer