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Tbio
USP42
Ubiquitin carboxyl-terminal hydrolase 42

Protein Summary
Description
Deubiquitinating enzyme which may play an important role during spermatogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306177
  • ENSP00000301962
  • ENSG00000106346
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
histone modification site profile
0.78
transcription factor binding site profile
0.75
transcription factor
0.74
tissue
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.07   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.999999825
p_ni:  1.73e-7
p_wrong:  1e-9
Data Source:  BioPlex
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.99984435
p_ni:  0.00015565
Score:  0.238
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.966
Data Source:  Reactome,STRINGDB
USP24
Tbio
Family:  Enzyme
Novelty:  0.07281326
Score:  0.922
Data Source:  STRINGDB
USP10
Tchem
Family:  Enzyme
Novelty:  0.05830541
Score:  0.914
Data Source:  STRINGDB
KLHL18
Tdark
Novelty:  0.52915213
Score:  0.809
Data Source:  STRINGDB
RCE1
Tchem
Family:  Enzyme
Novelty:  0.01209847
Score:  0.634
Data Source:  STRINGDB
ANKRD61
Tdark
Novelty:  5.65217391
Score:  0.606
Data Source:  STRINGDB
UBQLN1
Tbio
Novelty:  0.00921991
Score:  0.59
Data Source:  STRINGDB
ZKSCAN5
Tdark
Family:  TF
Novelty:  0.09717066
Score:  0.56
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Ub-specific processing proteases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Ub-specific processing proteases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
5
5
97.9
reticulocyte measurement
3
4
5
96.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
97.9
reticulocyte measurement
5
96.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 42
VGNC:4559
472287
Macaque
ubiquitin specific peptidase 42
703559
Mouse
MGI:1924050
76800
Rat
RGD:1305231
288482
Dog
ubiquitin specific peptidase 42
VGNC:54087
479754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 42
Macaque
ubiquitin specific peptidase 42
Mouse
Rat
Dog
ubiquitin specific peptidase 42
Publication Statistics
PubMed Score 16.07
PubMed score by year
PubTator Score 5.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title