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Tbio
VPS37B
Vacuolar protein sorting-associated protein 37B

Protein Summary
Description
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267202
  • ENSP00000267202
  • ENSG00000139722
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
interacting protein
0.86
cellular component
0.67
gene perturbation
0.63
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.36   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.36   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
18
19
98
waist-hip ratio
1
17
17
97.9
waist circumference
1
11
11
96.1
BMI-adjusted waist circumference
1
9
9
92.6
5
3
1
1.1
88.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
19
98
waist-hip ratio
17
97.9
waist circumference
11
96.1
BMI-adjusted waist circumference
9
92.6
1
1.1
88.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1916724
330192
Rat
RGD:1304576
288659
Horse
VPS37B, ESCRT-I subunit
VGNC:24926
100058900
Pig
VPS37B, ESCRT-I subunit
100152918
Opossum
VPS37B, ESCRT-I subunit
100022642
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
VPS37B, ESCRT-I subunit
Pig
VPS37B, ESCRT-I subunit
Opossum
VPS37B, ESCRT-I subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H9H4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Assembly Of The HIV Virion (R-HSA-175474)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly Of The HIV Virion
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Assembly Of The HIV Virion
Autophagy
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (52)
1 – 10 of 52
UBAP1
Tbio
Novelty:  0.02276845
p_int:  0.999999439
p_ni:  5.61e-7
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999108
p_ni:  8.91e-7
p_wrong:  1e-9
Score:  0.525
Data Source:  BioPlex,STRINGDB
VPS28
Tbio
Novelty:  0.02927315
p_int:  0.99999857
p_ni:  6.2e-8
p_wrong:  0.000001369
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.999
Data Source:  Reactome,STRINGDB
MVB12A
Tbio
Novelty:  0.09794
Score:  0.997
Data Source:  Reactome,STRINGDB
MVB12B
Tbio
Novelty:  0.15964868
Score:  0.994
Data Source:  Reactome,STRINGDB
VPS4A
Tbio
Novelty:  0.01508121
Score:  0.979
Data Source:  STRINGDB
VPS36
Tbio
Novelty:  0.03382542
Score:  0.972
Data Source:  Reactome,STRINGDB
VPS25
Tbio
Novelty:  0.03002488
Score:  0.97
Data Source:  Reactome,STRINGDB
CHMP6
Tbio
Novelty:  0.02931
Score:  0.969
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.36

PubMed score by year
PubTator Score  0.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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