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Tbio
AGO3
Protein argonaute-3

Protein Summary
Description
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity but only on select RNAs bearing 5'- and 3'-flanking sequences to the region of guide-target complementarity (PubMed:29040713). This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluste ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246314
  • ENSP00000246314
  • ENSG00000126070
  • ENST00000373191
  • ENSP00000362287

Symbol
  • EIF2C3
  • EIF2C3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
biological process
0.81
interacting protein
0.77
protein domain
0.73
pathway
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.66   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.66   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (36)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (30)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (208)
1 – 10 of 208
LONRF3
Tdark
Family: Enzyme
Novelty: 1.01853217
p_int: 0.999997875
p_ni: 0.000001926
p_wrong: 1.99e-7
Score: 0.324
Data Source: BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int: 0.999993527
p_ni: 0.000006471
p_wrong: 1e-9
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.999960866
p_ni: 0.000039134
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999912341
p_ni: 0.000087658
p_wrong: 1e-9
Data Source: BioPlex
AGO1
Tbio
Novelty: 0.00157424
p_int: 0.99907898
p_ni: 0.00092102
Score: 0.974
Data Source: BioPlex,STRINGDB
AP3B1
Tbio
Novelty: 0.03117931
p_int: 0.995313849
p_ni: 0.004686151
Score: 0.734
Data Source: BioPlex,STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
p_int: 0.994401235
p_ni: 0.005598765
Score: 0.175
Data Source: BioPlex,STRINGDB
AP3S1
Tbio
Novelty: 0.12425009
p_int: 0.991205917
p_ni: 0.008794083
Score: 0.719
Data Source: BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
p_int: 0.972845844
p_ni: 0.027154156
Score: 0.547
Data Source: BioPlex,STRINGDB
AP3D1
Tbio
Novelty: 0.04425592
p_int: 0.970227832
p_ni: 0.029772168
Score: 0.829
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  44.66

PubMed score by year
PubTator Score  24.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer