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Tbio
RMI1
RecQ-mediated genome instability protein 1

Protein Summary
Description
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325875
  • ENSP00000317039
  • ENSG00000178966

Symbol
  • C9orf76
  • BLAP75
  • FAAP75
  • C9orf76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
kinase perturbation
0.91
transcription factor
0.71
transcription factor perturbation
0.68
histone modification site profile
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.61   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.61   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
80
sex hormone-binding globulin measurement
4
1
4
66.4
testosterone measurement
1
1
1
42.5
triglyceride measurement
1
1
1
19.6
body fat distribution
2
1
4
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
80
sex hormone-binding globulin measurement
4
66.4
testosterone measurement
1
42.5
triglyceride measurement
1
19.6
body fat distribution
4
10.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RecQ mediated genome instability 1
714013
Mouse
MGI:1921636
74386
Rat
RGD:1310671
306734
Dog
RecQ mediated genome instability 1
VGNC:45608
100684392
Horse
RecQ mediated genome instability 1
VGNC:22412
100052791
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RecQ mediated genome instability 1
Mouse
Rat
Dog
RecQ mediated genome instability 1
Horse
RecQ mediated genome instability 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H9A7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
G2/M Checkpoints
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
G2/M Checkpoints
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (148)
1 – 10 of 148
RMI2
Tbio
Novelty: 0.02516878
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CCDC69
Tdark
Novelty: 0.37983713
p_int: 0.999999922
p_ni: 6.1e-8
p_wrong: 1.7e-8
Score: 0.809
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.999980539
p_ni: 0.000015504
p_wrong: 0.000003957
Data Source: BioPlex
DCAF15
Tdark
Novelty: 0.13476661
p_int: 0.999938615
p_ni: 0.000056924
p_wrong: 0.000004461
Score: 0.241
Data Source: BioPlex,STRINGDB
MARCKSL1
Tbio
Novelty: 0.01290798
p_int: 0.999792816
p_ni: 0.000032196
p_wrong: 0.000174988
Score: 0.71
Data Source: BioPlex,STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
p_int: 0.999719712
p_ni: 0.000280286
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RPL23A
Tbio
Novelty: 0.02951947
p_int: 0.999318566
p_ni: 0.000012409
p_wrong: 0.000669025
Data Source: BioPlex
FANCF
Tchem
Novelty: 0.01745498
Score: 0.999
Data Source: STRINGDB
CENPS
Tbio
Novelty: 0.0085893
Score: 0.999
Data Source: STRINGDB
FANCA
Tbio
Novelty: 0.00324947
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  82.61

PubMed score by year
PubTator Score  41.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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