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Tdark
CNOT10
CCR4-NOT transcription complex subunit 10

Protein Summary
Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328834
  • ENSP00000330060
  • ENSG00000182973
  • ENST00000331889
  • ENSP00000329376
  • ENST00000454516
  • ENSP00000399862
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor binding site profile
0.93
kinase perturbation
0.88
histone modification site profile
0.8
protein complex
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.13   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
2
2
2
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
2
71.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 10
VGNC:7038
470780
Macaque
CCR4-NOT transcription complex subunit 10
704986
Mouse
MGI:1926143
78893
Rat
RGD:1359219
316034
Dog
CCR4-NOT transcription complex subunit 10
VGNC:39411
612778
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CCR4-NOT transcription complex subunit 10
Macaque
CCR4-NOT transcription complex subunit 10
Mouse
Rat
Dog
CCR4-NOT transcription complex subunit 10
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H9A5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (71)
1 – 10 of 71
CNOT6L
Tbio
Novelty:  0.06038336
p_int:  0.999998232
p_ni:  0.000001768
Score:  0.992
Data Source:  BioPlex,STRINGDB
CNOT6
Tbio
Novelty:  0.03605299
p_int:  0.999997426
p_ni:  0.000002574
Score:  0.992
Data Source:  BioPlex,STRINGDB
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999995824
p_ni:  0.000004176
Score:  0.732
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999988947
p_ni:  0.00001105
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CNOT2
Tbio
Novelty:  0.01886737
p_int:  0.999980434
p_ni:  0.000019566
Score:  0.982
Data Source:  BioPlex,STRINGDB
TNKS1BP1
Tbio
Family:  Enzyme
Novelty:  0.21682007
p_int:  0.999976746
p_ni:  0.000023254
Score:  0.977
Data Source:  BioPlex,STRINGDB
CNOT9
Tbio
Novelty:  0.05592835
p_int:  0.999969513
p_ni:  0.000030487
Score:  0.977
Data Source:  BioPlex,STRINGDB
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999952804
p_ni:  0.000047196
Score:  0.759
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999941162
p_ni:  0.000058838
Score:  0.973
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999932172
p_ni:  0.000067652
p_wrong:  1.75e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  2.13

PubMed score by year
PubTator Score  0.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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