Tdark CNOT10 CCR4-NOT transcription complex subunit 10

Protein Summary

Description

Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.

Uniprot Accession IDs

• Q9H9A5
• B7Z7L1
• F8WAF2
• Q9BU30
• Q9H5J7
• Q9H8X1
• Q9H9W0
• Q9HAH3
• Q9UFJ2

Gene Name

• CNOT10

Ensembl ID

• ENST00000328834
• ENSP00000330060
• ENSG00000182973
• ENST00000331889
• ENSP00000329376
• ENST00000454516
• ENSP00000399862

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor binding site profile	0.93
kinase perturbation	0.88
histone modification site profile	0.8
protein complex	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.58   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0