Protein Classes
Protein Summary
Plays a role in the physiological regulation of the intracellular CoA concentration. This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]
- ENST00000239231
- ENSP00000239231
- ENSG00000120137
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
microRNA | 0.82 | ||
virus perturbation | 0.79 | ||
transcription factor binding site profile | 0.77 | ||
histone modification site profile | 0.7 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.67 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 210 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.67 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 210 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pantothenate kinase 3 | VGNC:4117 | 462250 | |||||
Macaque | pantothenate kinase 3 | 100427204 | ||||||
Mouse | MGI:2387464 | 211347 | ||||||
Rat | RGD:1310531 | 360511 | ||||||
Dog | pantothenate kinase 3 | VGNC:44252 | 489133 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pantothenate kinase 3 | |||||
Macaque | pantothenate kinase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pantothenate kinase 3 | |||||
Protein Structure (9 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (9)
Reactome (5)
KEGG (2)
PathwayCommons (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Coenzyme A biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Reactome | Vitamin B5 (pantothenate) metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Coenzyme A biosynthesis | ||||
Metabolism | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Vitamin B5 (pantothenate) metabolism | ||||
Gene Ontology Terms (8)
Functions (5)
Components (1)
Processes (2)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (26)
1 – 10 of 26
PANK2
Family: Kinase
Novelty: 0.00465551
p_int: 0.999999997
p_wrong: 3e-9
Data Source: BioPlex
COASY
Family: Enzyme
Novelty: 0.00294867
Score: 0.977
Data Source: STRINGDB
PPCS
Family: Enzyme
Novelty: 0.03813202
Score: 0.957
Data Source: STRINGDB
PPCDC
Family: Enzyme
Novelty: 0.0322534
Score: 0.956
Data Source: STRINGDB
ENPP3
Family: Enzyme
Novelty: 0.00414129
Score: 0.902
Data Source: STRINGDB
ENPP1
Family: Enzyme
Novelty: 0.00256132
Score: 0.902
Data Source: STRINGDB
VNN2
Novelty: 0.02286648
Score: 0.71
Data Source: STRINGDB
VNN1
Family: Enzyme
Novelty: 0.0144646
Score: 0.69
Data Source: STRINGDB
VNN3
Novelty: 0.11036559
Score: 0.658
Data Source: STRINGDB
GGA3
Novelty: 0.01898553
Score: 0.534
Data Source: STRINGDB
Publication Statistics
PubMed Score 11.67
PubMed score by year
PubTator Score 3.85
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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