Protein Summary
Plays a role in the physiological regulation of the intracellular CoA concentration. This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]
- ENST00000239231
- ENSP00000239231
- ENSG00000120137
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.88 | ||
microRNA | 0.82 | ||
virus perturbation | 0.79 | ||
transcription factor binding site profile | 0.77 | ||
histone modification site profile | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.78 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 210 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.78 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 210 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (26)
Nearest Tclin Targets
Pathways (9)
Reactome (5)
KEGG (2)
PathwayCommons (1)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Coenzyme A biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Reactome | Vitamin B5 (pantothenate) metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Coenzyme A biosynthesis | ||||
Metabolism | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Vitamin B5 (pantothenate) metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (5)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (0)
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IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pantothenate kinase 3 | VGNC:4117 | 462250 | |||||
Macaque | pantothenate kinase 3 | 100427204 | ||||||
Mouse | MGI:2387464 | 211347 | ||||||
Rat | RGD:1310531 | 360511 | ||||||
Dog | pantothenate kinase 3 | VGNC:44252 | 489133 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pantothenate kinase 3 | |||||
Macaque | pantothenate kinase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pantothenate kinase 3 | |||||
Publication Statistics
PubMed Score 12.78
PubMed score by year
PubTator Score 3.85
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (12)
GeneRif Annotations (3)
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