Tchem PANK3 Pantothenate kinase 3

Protein Summary

Description

Plays a role in the physiological regulation of the intracellular CoA concentration. This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H999
• D3DQL1
• Q53FJ9
• Q7RTX4
• hPanK3

Gene Name

• PANK3

Ensembl ID

• ENST00000239231
• ENSP00000239231
• ENSG00000120137

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
microRNA	0.82
virus perturbation	0.79
transcription factor binding site profile	0.77
histone modification site profile	0.7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.78   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.78   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Active Ligands (1)

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1 – 1 of 1

CHEMBL3410246

PANK3Tchem Kinase

pIC50 : 7.6

Protein-Protein Interactions (26)

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1 – 10 of 26

• See Interactions on String-DB

PANK2

Tbio

Family:  Kinase

Novelty:  0.00465551

p_int:  0.999999997

p_wrong:  3e-9

Data Source:  BioPlex

COASY

Tbio

Family:  Enzyme

Novelty:  0.00294867

Score:  0.977

Data Source:  STRINGDB

PPCS

Tbio

Family:  Enzyme

Novelty:  0.03813202

Score:  0.957

Data Source:  STRINGDB

PPCDC

Tbio

Family:  Enzyme

Novelty:  0.0322534

Score:  0.956

Data Source:  STRINGDB

ENPP3

Tchem

Family:  Enzyme

Novelty:  0.00414129

Score:  0.902

Data Source:  STRINGDB

ENPP1

Tchem

Family:  Enzyme

Novelty:  0.00256132

Score:  0.902

Data Source:  STRINGDB

VNN2

Tbio

Novelty:  0.02286648

Score:  0.71

Data Source:  STRINGDB

VNN1

Tchem

Family:  Enzyme

Novelty:  0.0144646

Score:  0.69

Data Source:  STRINGDB

VNN3

Tbio

Novelty:  0.11036559

Score:  0.658

Data Source:  STRINGDB

GGA3

Tbio

Novelty:  0.01898553

Score:  0.534

Data Source:  STRINGDB

Pathways (9)

Reactome (5)

KEGG (2)

PathwayCommons (1)

UniProt (1)

Coenzyme A biosynthesis (R-HSA-196783)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Coenzyme A biosynthesis	8 targets	R-HSA-196783
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Reactome	Metabolism of water-soluble vitamins and cofactors	122 targets	R-HSA-196849
Reactome	Vitamin B5 (pantothenate) metabolism	17 targets	R-HSA-199220

Name	Explore in Pharos	Explore in Source
Coenzyme A biosynthesis	8 targets	R-HSA-196783
Metabolism	2112 targets	R-HSA-1430728
Metabolism of vitamins and cofactors	188 targets	R-HSA-196854
Metabolism of water-soluble vitamins and cofactors	122 targets	R-HSA-196849
Vitamin B5 (pantothenate) metabolism	17 targets	R-HSA-199220

Gene Ontology Terms (8)

Functions (5)

Components (1)

Processes (2)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
acetyl-CoA binding	Inferred from Direct Assay (IDA)	UniProtKB
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
pantothenate kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
vitamin binding	Inferred from Direct Assay (IDA)	UniProtKB

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ATP-binding
Coenzyme A biosynthesis
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Reference proteome
Transferase

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
homeostasis/metabolism phenotype
skeleton phenotype

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	pantothenate kinase 3	VGNC:4117	462250
Macaque	pantothenate kinase 3		100427204
Mouse	pantothenate kinase 3	MGI:2387464	211347
Rat	pantothenate kinase 3	RGD:1310531	360511
Dog	pantothenate kinase 3	VGNC:44252	489133

Species	Name	OMA	EggNOG	Inparanoid
Chimp	pantothenate kinase 3
Macaque	pantothenate kinase 3
Mouse	pantothenate kinase 3
Rat	pantothenate kinase 3
Dog	pantothenate kinase 3

Publication Statistics

PubMed Score 12.78

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PubTator Score 3.85

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