Tbio ARMT1 Protein-glutamate O-methyltransferase

Protein Summary

Description

O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is involved in the DNA damage response.

Uniprot Accession IDs

• Q9H993
• Q96FC6
• Q9UFY5

Gene Name

• ARMT1

Ensembl ID

• ENST00000367294
• ENSP00000356263
• ENSG00000146476

Symbol

• C6orf211
• C6orf211

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.75
transcription factor binding site profile	0.74
histone modification site profile	0.72
kinase perturbation	0.66
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.2   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.2   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0