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Tbio
ACTR8
Actin-related protein 8

Protein Summary
Description
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335754
  • ENSP00000336842
  • ENSG00000113812
  • ENST00000482349
  • ENSP00000419429

Symbol
  • ARP8
  • INO80N
  • ARP8
  • hArp8
  • INO80N
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
molecular function
0.76
hub protein
0.71
small molecule perturbation
0.66
tissue
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.21   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.21   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ARP8 actin related protein 8 homolog
460453
Macaque
ARP8 actin related protein 8 homolog
693539
Mouse
MGI:1860775
56249
Rat
RGD:1311878
361107
Dog
ARP8 actin related protein 8 homolog
VGNC:37557
607274
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ARP8 actin related protein 8 homolog
Macaque
ARP8 actin related protein 8 homolog
Mouse
Rat
Dog
ARP8 actin related protein 8 homolog
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H981-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
DNA Damage Recognition in GG-NER (R-HSA-5696394)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Deubiquitination
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Damage Recognition in GG-NER
DNA Repair
Deubiquitination
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (85)
1 – 10 of 85
INO80
Tbio
Family: Enzyme
Novelty: 0.09412936
p_int: 0.99999998
p_ni: 2e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
RUVBL1
Tbio
Novelty: 0.0089115
p_int: 0.999999977
p_ni: 2.3e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
RUVBL2
Tbio
Novelty: 0.01129017
p_int: 0.999999962
p_ni: 3.8e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
INO80C
Tdark
Novelty: 0.04242834
p_int: 0.999999957
p_ni: 4.3e-8
Score: 0.975
Data Source: BioPlex,STRINGDB
UCHL5
Tbio
Family: Enzyme
Novelty: 0.01486265
p_int: 0.999999468
p_ni: 5.32e-7
Score: 0.959
Data Source: BioPlex,STRINGDB
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.999917001
p_ni: 0.000082984
p_wrong: 1.4e-8
Score: 0.192
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.999689127
p_ni: 0.000310868
p_wrong: 5e-9
Score: 0.218
Data Source: BioPlex,STRINGDB
AMY1A
Tchem
Family: Enzyme
Novelty: 0.00210045
p_int: 0.901703444
p_ni: 0.098296556
Data Source: BioPlex
DCAF10
Tdark
Novelty: 2.6713128
p_int: 0.781542094
p_ni: 0.218457906
Score: 0.303
Data Source: BioPlex,STRINGDB
ACTR5
Tbio
Novelty: 0.15502033
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.21

PubMed score by year
PubTator Score  6.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer