Tbio MED20 Mediator of RNA polymerase II transcription subunit 20

Protein Summary

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

Uniprot Accession IDs

• Q9H944
• B4DE08
• O95821
• Q5T8J4
• Q9Y429

Gene Name

• MED20

Ensembl ID

• ENST00000265350
• ENSP00000265350
• ENSG00000124641
• ENST00000409312
• ENSP00000386816

Symbol

• TRFP
• SRB2
• TRFP
• PRO0213

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
transcription factor binding site profile	0.84
histone modification site profile	0.81
transcription factor perturbation	0.61
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Mediator Of Rna Polymerase Ii Transcription Subunit 20

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Mediator Of Rna Polymerase Ii Transcription Subunit 20

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.66   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 89   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.66   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0