Tbio MTHFD2L Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2

Protein Summary

Uniprot Accession IDs

• Q9H903
• Q6P079
• Q8N560

Gene Name

• MTHFD2L

Ensembl ID

• ENST00000325278
• ENSP00000321984
• ENSG00000163738
• ENST00000395759
• ENSP00000379108
• ENST00000429519
• ENSP00000391327

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
transcription factor perturbation	0.8
protein domain	0.73
tissue sample	0.67
transcription factor	0.66

Protein Classes

PANTHER Classes

Protein / Hydrolase / Probable Bifunctional Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase 2

Protein / ... / Dehydrogenase / Probable Bifunctional Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Probable Bifunctional Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.33   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.33   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0