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Tbio
IPPK
Inositol-pentakisphosphate 2-kinase

Protein Classes
Protein Summary
Description
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis. The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287996
  • ENSP00000287996
  • ENSG00000127080

Symbol
  • C9orf12
  • IP5K
  • IPK1
  • C9orf12
  • INSP5K2
  • bA476B13.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
histone modification site profile
0.87
transcription factor binding site profile
0.85
kinase perturbation
0.71
tissue sample
0.69


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.46   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.46   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
3
3
87.3
myeloid white cell count
1
1
1
62.1
high density lipoprotein cholesterol measurement
1
1
1
23.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
87.3
myeloid white cell count
1
62.1
high density lipoprotein cholesterol measurement
1
23.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol-pentakisphosphate 2-kinase
VGNC:4768
740083
Macaque
inositol-pentakisphosphate 2-kinase
705937
Mouse
MGI:1922928
75678
Rat
RGD:1311271
306808
Dog
inositol-pentakisphosphate 2-kinase
VGNC:42071
484215
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol-pentakisphosphate 2-kinase
Macaque
inositol-pentakisphosphate 2-kinase
Mouse
Rat
Dog
inositol-pentakisphosphate 2-kinase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H8X2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IPs in the nucleus
Reactome
Synthesis of pyrophosphates in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IPs in the nucleus
Synthesis of pyrophosphates in the cytosol
Protein-Protein Interactions (123)
1 – 10 of 123
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 1
Score: 0.543
Data Source: BioPlex,STRINGDB
TYRO3
Tchem
Family: Kinase
Novelty: 0.00233016
p_int: 0.999997449
p_ni: 0.000002541
p_wrong: 1e-8
Data Source: BioPlex
ENPP4
Tbio
Family: Enzyme
Novelty: 0.09897251
p_int: 0.999980238
p_ni: 0.000011119
p_wrong: 0.000008644
Data Source: BioPlex
SELENOT
Tbio
Novelty: 0.02480242
p_int: 0.999970444
p_ni: 0.000029205
p_wrong: 3.51e-7
Data Source: BioPlex
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
p_int: 0.999951609
p_ni: 0.000048391
Data Source: BioPlex
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999905262
p_ni: 0.000020439
p_wrong: 0.000074299
Data Source: BioPlex
SC5D
Tbio
Family: Enzyme
Novelty: 0.02446366
p_int: 0.99971428
p_ni: 0.000283038
p_wrong: 0.000002682
Data Source: BioPlex
CERS4
Tbio
Family: TF
Novelty: 0.01741762
p_int: 0.999674818
p_ni: 0.000017945
p_wrong: 0.000307237
Score: 0.511
Data Source: BioPlex,STRINGDB
CERS5
Tbio
Family: TF
Novelty: 0.02984012
p_int: 0.9992879
p_ni: 0.000701075
p_wrong: 0.000011025
Data Source: BioPlex
ATP2B3
Tbio
Family: Transporter
Novelty: 0.00901493
p_int: 0.999184633
p_ni: 0.000815367
Data Source: BioPlex
Publication Statistics
PubMed Score  48.46

PubMed score by year
PubTator Score  17.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer