Tbio TRIM45 Tripartite motif-containing protein 45

Protein Summary

Description

May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q9H8W5
• Q53GN0
• Q5T2K4
• Q5T2K5
• Q8IYV6

Gene Name

• TRIM45

Ensembl ID

• ENST00000256649
• ENSP00000256649
• ENSG00000134253
• ENST00000369464
• ENSP00000358476

Symbol

• RNF99
• RNF99

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
histone modification site profile	0.9
interacting protein	0.69
cell line	0.65
small molecule perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.01   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.01   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0