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Tbio
MINDY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

Protein Summary
Description
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277632
  • ENSP00000277632
  • ENSG00000148481

Symbol
  • C10orf97
  • CARP
  • DERP5
  • FAM188A
  • CARP
  • DERP5
  • my042
  • MST126
  • FAM188A
  • MSTP126
  • C10orf97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.51   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.51   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
49.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MINDY lysine 48 deubiquitinase 3
VGNC:3849
450324
Macaque
MINDY lysine 48 deubiquitinase 3
699009
Mouse
MGI:1914210
66960
Rat
RGD:1309605
291320
Dog
MINDY lysine 48 deubiquitinase 3
VGNC:49794
487118
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MINDY lysine 48 deubiquitinase 3
Macaque
MINDY lysine 48 deubiquitinase 3
Mouse
Rat
Dog
MINDY lysine 48 deubiquitinase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H8M7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (54)
1 – 10 of 54
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.999769237
p_ni:  0.000230647
p_wrong:  1.15e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999757979
p_ni:  0.000242021
Data Source:  BioPlex
KIFC1
Tchem
Novelty:  0.00982095
p_int:  0.9997408
p_ni:  0.0002592
Score:  0.211
Data Source:  BioPlex,STRINGDB
CD19
Tclin
Novelty:  0.0001816
p_int:  0.999499256
p_ni:  0.000500744
Score:  0.207
Data Source:  BioPlex,STRINGDB
SCAF8
Tbio
Novelty:  0.1650699
p_int:  0.99941855
p_ni:  0.000581446
p_wrong:  4e-9
Score:  0.27
Data Source:  BioPlex,STRINGDB
RNF25
Tbio
Family:  Enzyme
Novelty:  0.08945219
p_int:  0.998605654
p_ni:  0.001394345
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
LANCL2
Tchem
Novelty:  0.06086418
p_int:  0.996382089
p_ni:  0.00361791
p_wrong:  1e-9
Score:  0.545
Data Source:  BioPlex,STRINGDB
ZNF644
Tbio
Family:  TF
Novelty:  0.12816167
p_int:  0.993168794
p_ni:  0.006830549
p_wrong:  6.57e-7
Data Source:  BioPlex
MPP6
Tbio
Novelty:  0.08883057
p_int:  0.98353445
p_ni:  0.01646555
Score:  0.19
Data Source:  BioPlex,STRINGDB
DOK2
Tbio
Novelty:  0.02651438
p_int:  0.968557897
p_ni:  0.031442103
Score:  0.309
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  33.51

PubMed score by year
PubTator Score  1.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer