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Tchem
BRD9
Bromodomain-containing protein 9

Protein Summary
Description
Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000467963
  • ENSP00000419765
  • ENSG00000028310
  • ENST00000483173
  • ENSP00000419845

Symbol
  • PRO9856
  • LAVS3040
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.85
disease perturbation
0.79
transcription factor binding site profile
0.74
cell line
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.94   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.94   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (31)
1 – 5 of 31
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (47)
1 – 10 of 47
BCL7C
Tdark
Novelty: 0.31203802
p_int: 0.999999946
p_ni: 5.2e-8
p_wrong: 1e-9
Score: 0.839
Data Source: BioPlex,STRINGDB
BCL7A
Tbio
Novelty: 0.07026394
p_int: 0.999999866
p_ni: 1.32e-7
p_wrong: 3e-9
Score: 0.818
Data Source: BioPlex,STRINGDB
SS18
Tbio
Novelty: 0.00915548
p_int: 0.99999973
p_ni: 1.64e-7
p_wrong: 1.05e-7
Score: 0.925
Data Source: BioPlex,STRINGDB
SMARCD1
Tbio
Novelty: 0.03176642
p_int: 0.999999579
p_ni: 4.2e-7
p_wrong: 1e-9
Score: 0.901
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.02625321
p_int: 0.99968406
p_ni: 0.000236391
p_wrong: 0.00007955
Score: 0.927
Data Source: BioPlex,STRINGDB
ARID2
Tbio
Family: TF
Novelty: 0.01767212
Score: 0.78
Data Source: STRINGDB
ATAD2B
Tchem
Family: Epigenetic
Novelty: 0.33596787
Score: 0.73
Data Source: STRINGDB
SMARCA4
Tchem
Family: Epigenetic
Novelty: 0.00112496
Score: 0.714
Data Source: STRINGDB
SMARCA2
Tchem
Family: Epigenetic
Novelty: 0.00231554
Score: 0.711
Data Source: STRINGDB
SMARCE1
Tbio
Family: TF
Novelty: 0.01748089
Score: 0.705
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.94

PubMed score by year
PubTator Score  16.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer