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Tchem
BRD9
Bromodomain-containing protein 9

Protein Summary
Description
Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000467963
  • ENSP00000419765
  • ENSG00000028310
  • ENST00000483173
  • ENSP00000419845

Symbol
  • PRO9856
  • LAVS3040
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.85
disease perturbation
0.79
transcription factor binding site profile
0.74
cell line
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.49   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.49   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 111
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0