BRD9
Bromodomain-containing protein 9
Protein Summary
Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
- ENST00000467963
- ENSP00000419765
- ENSG00000028310
- ENST00000483173
- ENSP00000419845
- PRO9856
- LAVS3040
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.88 | ||
histone modification site profile | 0.85 | ||
disease perturbation | 0.79 | ||
transcription factor binding site profile | 0.74 | ||
cell line | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.49 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 137 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.49 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 137 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 111
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0