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Tchem
BRD9
Bromodomain-containing protein 9

Protein Summary
Description
Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000467963
  • ENSP00000419765
  • ENSG00000028310
  • ENST00000483173
  • ENSP00000419845

Symbol
  • PRO9856
  • LAVS3040
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.85
disease perturbation
0.79
transcription factor binding site profile
0.74
cell line
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 101
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (101)
Bromosporine
Rendered image for Bromosporine
CHEMBL4436408
Rendered image for CHEMBL4436408
NI-57
Rendered image for NI-57
CHEMBL4102050
Rendered image for CHEMBL4102050
CHEMBL3108800
Rendered image for CHEMBL3108800
CHEMBL4586175
Rendered image for CHEMBL4586175
CHEMBL4103077
Rendered image for CHEMBL4103077
CHEMBL4076056
Rendered image for CHEMBL4076056
BI-9564
Rendered image for BI-9564
I-BRD9
Rendered image for I-BRD9
Protein-Protein Interactions (47)
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999999946
p_ni:  5.2e-8
p_wrong:  1e-9
Score:  0.839
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999999866
p_ni:  1.32e-7
p_wrong:  3e-9
Score:  0.818
Data Source:  BioPlex,STRINGDB
SS18
Tbio
Novelty:  0.00915548
p_int:  0.99999973
p_ni:  1.64e-7
p_wrong:  1.05e-7
Score:  0.925
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999999579
p_ni:  4.2e-7
p_wrong:  1e-9
Score:  0.901
Data Source:  BioPlex,STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.99968406
p_ni:  0.000236391
p_wrong:  0.00007955
Score:  0.927
Data Source:  BioPlex,STRINGDB
ARID2
Tbio
Family:  TF
Novelty:  0.01767212
Score:  0.78
Data Source:  STRINGDB
ATAD2B
Tchem
Family:  Epigenetic
Novelty:  0.33596787
Score:  0.73
Data Source:  STRINGDB
SMARCA4
Tchem
Family:  Epigenetic
Novelty:  0.00112496
Score:  0.714
Data Source:  STRINGDB
SMARCA2
Tchem
Family:  Epigenetic
Novelty:  0.00231554
Score:  0.711
Data Source:  STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
Score:  0.705
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
8.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
8.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain-containing protein 9
738370
Macaque
bromodomain containing 9
709235
Mouse
MGI:2145317
105246
Rat
RGD:1307359
308067
Dog
bromodomain containing 9
VGNC:49822
609435
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain-containing protein 9
Macaque
bromodomain containing 9
Mouse
Rat
Dog
bromodomain containing 9
Publication Statistics
PubMed Score 40.21
PubMed score by year
PubTator Score 16.42
PubTator score by year
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Related Publications
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PMID
Year
Title