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Tdark
COQ10B
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial

Protein Summary
Description
Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263960
  • ENSP00000263960
  • ENSG00000115520
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
histone modification site profile
0.84
transcription factor perturbation
0.84
kinase perturbation
0.76
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.26   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.26   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
COQ2
Tbio
Family:  Enzyme
Novelty:  0.00575853
Score:  0.816
Data Source:  STRINGDB
COQ3
Tbio
Family:  Enzyme
Novelty:  0.03013258
Score:  0.779
Data Source:  STRINGDB
COQ5
Tbio
Family:  Enzyme
Novelty:  0.04664953
Score:  0.774
Data Source:  STRINGDB
COQ4
Tbio
Novelty:  0.03537017
Score:  0.745
Data Source:  STRINGDB
COQ9
Tbio
Novelty:  0.00740475
Score:  0.745
Data Source:  STRINGDB
ZNF786
Tdark
Family:  TF
Novelty:  10.67468525
Score:  0.731
Data Source:  STRINGDB
PDSS1
Tbio
Family:  Enzyme
Novelty:  0.01542427
Score:  0.728
Data Source:  STRINGDB
COQ7
Tbio
Family:  Enzyme
Novelty:  0.01010794
Score:  0.71
Data Source:  STRINGDB
COQ6
Tbio
Family:  Enzyme
Novelty:  0.0290336
Score:  0.706
Data Source:  STRINGDB
COQ8B
Tchem
Family:  Kinase
Novelty:  0.02469308
Score:  0.702
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
0
1
80.7
7
4
1
1.1
74.1
1
1
0
1
57.3
Eczema
1
1
0
1
57.3
1
2
0
1.1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
80.7
1
1.1
74.1
0
1
57.3
Eczema
0
1
57.3
0
1.1
52
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q10B
VGNC:145
459851
Macaque
coenzyme Q10B
697432
Mouse
MGI:1915126
67876
Rat
RGD:1359509
301416
Dog
coenzyme Q10B
478853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coenzyme Q10B
Macaque
coenzyme Q10B
Mouse
Rat
Dog
coenzyme Q10B
Publication Statistics
PubMed Score 1.26
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title