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Tbio
MMRN2
Multimerin-2

Protein Summary
Description
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372027
  • ENSP00000361097
  • ENSG00000173269

Symbol
  • EMILIN3
  • EMILIN3
  • EMILIN-3
  • ENDOGLYX-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
transcription factor perturbation
0.68
virus
0.66
PubMedID
0.63
cell line
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.4   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.4   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (21)
1 – 10 of 21
CLEC14A
Tbio
Novelty:  0.03231666
Score:  0.868
Data Source:  STRINGDB
ZNF24
Tbio
Family:  TF
Novelty:  0.02954446
Score:  0.745
Data Source:  STRINGDB
AHSG
Tbio
Novelty:  0.00112502
Score:  0.67
Data Source:  STRINGDB
ARHGAP18
Tbio
Family:  Enzyme
Novelty:  0.10618156
Score:  0.66
Data Source:  STRINGDB
ADGRG1
Tbio
Family:  GPCR
Novelty:  0.00924718
Score:  0.651
Data Source:  STRINGDB
ISM1
Tbio
Novelty:  0.03082946
Score:  0.65
Data Source:  STRINGDB
FAM25A
Tdark
Novelty:  1.81526954
Score:  0.617
Data Source:  STRINGDB
ARL6IP5
Tbio
Novelty:  0.00871985
Score:  0.606
Data Source:  STRINGDB
APC2
Tbio
Novelty:  0.02034048
Score:  0.564
Data Source:  STRINGDB
AGAP5
Tdark
Family:  Enzyme
Novelty:  1.23602896
Score:  0.541
Data Source:  STRINGDB
Pathways (26)
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
VEGFA-VEGFR2 Signaling Pathway
WikiPathways
VEGFA-VEGFR2 Signaling Pathway
WikiPathways
VEGFA-VEGFR2 Signaling Pathway
WikiPathways
VEGFA-VEGFR2 Signaling Pathway
WikiPathways
VEGFA-VEGFR2 Signaling Pathway
Name
Explore in Pharos
Explore in Source
VEGFA-VEGFR2 Signaling Pathway
VEGFA-VEGFR2 Signaling Pathway
VEGFA-VEGFR2 Signaling Pathway
VEGFA-VEGFR2 Signaling Pathway
VEGFA-VEGFR2 Signaling Pathway
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
56.6
leukocyte count
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
56.6
leukocyte count
1
27.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
multimerin 2
VGNC:4785
450573
Macaque
multimerin 2
699306
Mouse
MGI:2385618
105450
Rat
RGD:1311461
306288
Dog
multimerin 2
VGNC:43292
489078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
multimerin 2
Macaque
multimerin 2
Mouse
Rat
Dog
multimerin 2
Publication Statistics
PubMed Score 9.40
PubMed score by year
PubTator Score 7.54
PubTator score by year