Protein Summary
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]
- ENST00000372027
- ENSP00000361097
- ENSG00000173269
- EMILIN3
- EMILIN3
- EMILIN-3
- ENDOGLYX-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
tissue sample | 0.68 | ||
transcription factor perturbation | 0.68 | ||
virus | 0.66 | ||
PubMedID | 0.63 | ||
cell line | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.04 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 99 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.04 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 99 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0