Tbio NOL11 Nucleolar protein 11

Protein Summary

Description

Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.

Uniprot Accession IDs

• Q9H8H0
• B7Z5V9
• Q7L5S1
• Q9UG18

Gene Name

• NOL11

Ensembl ID

• ENST00000253247
• ENSP00000253247
• ENSG00000130935
• ENST00000581375
• ENSP00000463219

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
kinase perturbation	0.88
transcription factor perturbation	0.88
transcription factor binding site profile	0.84
cell type or tissue	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0