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Tbio
CAAP1
Caspase activity and apoptosis inhibitor 1

Protein Summary
Description
Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333916
  • ENSP00000369431
  • ENSG00000120159
  • ENST00000625311
  • ENSP00000487373

Symbol
  • C9orf82
  • CAAP
  • CAAP
  • C9orf82
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
histone modification site profile
0.8
transcription factor binding site profile
0.68
cell line
0.64
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
AKAP17A
Tbio
Family:  Enzyme
Novelty:  0.02860381
p_int:  0.967505368
p_ni:  0.032494632
Score:  0.825
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.808888713
p_ni:  0.191111287
Score:  0.535
Data Source:  BioPlex,STRINGDB
BFAR
Tbio
Novelty:  0.060376
Score:  0.648
Data Source:  STRINGDB
ANGEL2
Tbio
Novelty:  0.26130802
Score:  0.648
Data Source:  STRINGDB
API5
Tbio
Novelty:  0.02121052
Score:  0.63
Data Source:  STRINGDB
CSNK1G3
Tchem
Family:  Kinase
Novelty:  0.07584067
Score:  0.552
Data Source:  STRINGDB
RFLNA
Tbio
Novelty:  0.08580308
Score:  0.544
Data Source:  STRINGDB
MIER1
Tbio
Novelty:  0.00357772
Score:  0.529
Data Source:  STRINGDB
TMEM244
Tdark
Novelty:  1.63578426
Score:  0.491
Data Source:  STRINGDB
FAM173B
Tbio
Novelty:  0.02367461
Score:  0.49
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (101)
Find Similar Targets
Items per page:
1 – 5 of 101
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Viral Acute Myocarditis
WikiPathways
Viral Acute Myocarditis
WikiPathways
Viral Acute Myocarditis
WikiPathways
Viral Acute Myocarditis
WikiPathways
Viral Acute Myocarditis
Name
Explore in Pharos
Explore in Source
Viral Acute Myocarditis
Viral Acute Myocarditis
Viral Acute Myocarditis
Viral Acute Myocarditis
Viral Acute Myocarditis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
depressive symptom measurement
1
1
1
2.9
neuroticism measurement
1
1
1
2.9
wellbeing measurement
3
1
3
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
depressive symptom measurement
1
2.9
neuroticism measurement
1
2.9
wellbeing measurement
3
1.9
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caspase activity and apoptosis inhibitor 1
VGNC:4643
465025
Macaque
caspase activity and apoptosis inhibitor 1
707992
Mouse
MGI:1915020
67770
Dog
caspase activity and apoptosis inhibitor 1
VGNC:38618
474732
Horse
caspase activity and apoptosis inhibitor 1
VGNC:15969
100066904
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caspase activity and apoptosis inhibitor 1
Macaque
caspase activity and apoptosis inhibitor 1
Mouse
Dog
caspase activity and apoptosis inhibitor 1
Horse
caspase activity and apoptosis inhibitor 1
Publication Statistics
PubMed Score 70.76
PubMed score by year
PubTator Score 19.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title