You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KAT14
Cysteine-rich protein 2-binding protein

Protein Summary
Description
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000435364
  • ENSP00000392318
  • ENSG00000149474
  • ENST00000489634
  • ENSP00000425909

Symbol
  • CSRP2BP
  • ATAC2
  • CRP2BP
  • CSRP2BP
  • PRO1194
  • dJ717M23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
DR1
Tbio
Novelty:  0.00138571
p_int:  0.999999978
p_ni:  2.2e-8
Score:  0.953
Data Source:  BioPlex,STRINGDB
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.99999995
p_ni:  5e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
TADA3
Tbio
Novelty:  0.01743814
p_int:  0.999999751
p_ni:  2.49e-7
Score:  0.993
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999383
p_ni:  6.17e-7
Score:  0.973
Data Source:  BioPlex,STRINGDB
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.999930199
p_ni:  0.000069801
Score:  0.312
Data Source:  BioPlex,STRINGDB
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999907158
p_ni:  0.00009284
p_wrong:  2e-9
Score:  0.216
Data Source:  BioPlex,STRINGDB
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.999905353
p_ni:  0.000094647
Score:  0.795
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999828537
p_ni:  0.000171463
Score:  0.187
Data Source:  BioPlex,STRINGDB
SPERT
Tbio
Novelty:  0.12255061
p_int:  0.999716427
p_ni:  0.000283573
Score:  0.321
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999517636
p_ni:  0.000482364
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
59
red blood cell density measurement
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
59
red blood cell density measurement
1
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 5.67
PubMed score by year
PubTator Score 1.92
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title