Tbio KAT14 Cysteine-rich protein 2-binding protein

Protein Summary

Description

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle. CSRP2 is a protein containing two LIM domains, which are double zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an acetyltransferase domain. Although the encoded protein has been detected in the cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q9H8E8
• A2A2I5
• Q96GW6
• Q96IH3
• Q9HBF0
• Q9UIY5
• CSRP2-binding protein

Gene Name

• KAT14

Ensembl ID

• ENST00000435364
• ENSP00000392318
• ENSG00000149474
• ENST00000489634
• ENSP00000425909

Symbol

• CSRP2BP
• ATAC2
• CRP2BP
• CSRP2BP
• PRO1194
• dJ717M23.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (92)

Explore Interacting Targets

1 – 10 of 92

• See Interactions on String-DB

DR1

Tbio

Novelty:  0.00138571

p_int:  0.999999978

p_ni:  2.2e-8

Score:  0.953

Data Source:  BioPlex,STRINGDB

MBIP

Tbio

Novelty:  0.05807454

p_int:  0.99999995

p_ni:  5e-8

Score:  0.98

Data Source:  BioPlex,STRINGDB

TADA3

Tbio

Novelty:  0.01743814

p_int:  0.999999751

p_ni:  2.49e-7

Score:  0.993

Data Source:  BioPlex,STRINGDB

WDR5

Tchem

Novelty:  0.0059945

p_int:  0.999999383

p_ni:  6.17e-7

Score:  0.973

Data Source:  BioPlex,STRINGDB

CARD8

Tbio

Family:  Enzyme

Novelty:  0.0146799

p_int:  0.999930199

p_ni:  0.000069801

Score:  0.312

Data Source:  BioPlex,STRINGDB

IKZF5

Tbio

Family:  TF

Novelty:  0.36596327

p_int:  0.999907158

p_ni:  0.00009284

p_wrong:  2e-9

Score:  0.216

Data Source:  BioPlex,STRINGDB

POLE4

Tdark

Family:  Enzyme

Novelty:  0.23346084

p_int:  0.999905353

p_ni:  0.000094647

Score:  0.795

Data Source:  BioPlex,STRINGDB

PSME3

Tbio

Novelty:  0.01051254

p_int:  0.999828537

p_ni:  0.000171463

Score:  0.187

Data Source:  BioPlex,STRINGDB

SPERT

Tbio

Novelty:  0.12255061

p_int:  0.999716427

p_ni:  0.000283573

Score:  0.321

Data Source:  BioPlex,STRINGDB

LMO2

Tbio

Novelty:  0.0038279

p_int:  0.999517636

p_ni:  0.000482364

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Chromatin modifying enzymes (R-HSA-3247509)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	HATs acetylate histones	107 targets	R-HSA-3214847

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
HATs acetylate histones	107 targets	R-HSA-3214847

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (2)

Components (3)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
histone acetyltransferase activity	Inferred from Direct Assay (IDA)	MGI
LIM domain binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		59
red blood cell density measurement	EFO_0007978	1	1	1		52.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	1		59
red blood cell density measurement	EFO_0007978	1		52.7

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular hemoglobin concentration
red blood cell density measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	lysine acetyltransferase 14	MGI:1917264	228714
Zebrafish	lysine acetyltransferase 14	ZDB-GENE-040718-452	562636

Species	Name	OMA	EggNOG	Inparanoid
Mouse	lysine acetyltransferase 14
Zebrafish	lysine acetyltransferase 14

Publication Statistics

PubMed Score 5.67

PubMed score by year

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PubTator Score 1.92

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title