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Tdark
PRKRIP1
PRKR-interacting protein 1

Protein Summary
Description
Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397912
  • ENSP00000381010
  • ENSG00000128563
  • ENST00000496391
  • ENSP00000419270

Symbol
  • C114
  • KRBOX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
histone modification site profile
0.93
transcription factor binding site profile
0.82
tissue
0.77
cellular component
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.999999919
p_ni:  6.9e-8
p_wrong:  1.2e-8
Score:  0.95
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.999999259
p_ni:  7.39e-7
p_wrong:  2e-9
Score:  0.853
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.999966264
p_ni:  7.08e-7
p_wrong:  0.000033028
Data Source:  BioPlex
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999574722
p_ni:  0.000014469
p_wrong:  0.000410809
Score:  0.761
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.850333442
p_ni:  0.000270971
p_wrong:  0.149395587
Score:  0.951
Data Source:  BioPlex,STRINGDB
SNRPG
Tbio
Novelty:  0.1684808
Score:  0.932
Data Source:  STRINGDB
RBM22
Tbio
Novelty:  0.0536968
Score:  0.889
Data Source:  STRINGDB
CDC40
Tbio
Novelty:  0.03139044
Score:  0.886
Data Source:  STRINGDB
SNRPD1
Tbio
Novelty:  0.0136355
Score:  0.881
Data Source:  STRINGDB
SNRPD2
Tbio
Novelty:  0.02519503
Score:  0.877
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
2
1.1
90.3
insomnia measurement
1
2
0
1
54.2
glomerular filtration rate
1
1
1
40.7
creatinine measurement
1
1
1
39.6
circadian rhythm
2
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
90.3
insomnia measurement
0
1
54.2
glomerular filtration rate
1
40.7
creatinine measurement
1
39.6
circadian rhythm
2
21.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PRKR interacting protein 1
VGNC:50370
742160
Mouse
MGI:1914051
66801
Rat
RGD:1595708
498171
Dog
PRKR interacting protein 1
VGNC:49780
608112
Horse
PRKR interacting protein 1
VGNC:50493
106781523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PRKR interacting protein 1
Mouse
Rat
Dog
PRKR interacting protein 1
Horse
PRKR interacting protein 1
Publication Statistics
PubMed Score 4.14
PubMed score by year
PubTator Score 6.42
PubTator score by year
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Related Publications
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PMID
Year
Title