Tbio YY1AP1 YY1-associated protein 1

Protein Summary

Description

Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641). The encoded gene product presumably interacts with YY1 protein; however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H869
• B0QZ54
• B4DMP2
• B4E0I0
• D3DV96
• D3DV98
• H7BY62
• Q5VYZ1
• Q5VYZ4
• Q5VYZ7
• Q7L4C3
• Q7L5E2
• Q8IXA6
• Q8TEW5
• Q8TF04
• Q96HB6
• Q9BQ64
• Q9NV84

Gene Name

• YY1AP1

Ensembl ID

• ENST00000295566
• ENSP00000295566
• ENSG00000163374
• ENST00000311573
• ENSP00000311138
• ENST00000347088
• ENSP00000316079
• ENST00000355499
• ENSP00000347686
• ENST00000359205
• ENSP00000352134
• ENST00000361831
• ENSP00000355298
• ENST00000368330
• ENSP00000357314
• ENST00000368339
• ENSP00000357323
• ENST00000368340
• ENSP00000357324
• ENST00000404643
• ENSP00000385390
• ENST00000407221
• ENSP00000385791

Symbol

• HCCA2
• YY1AP
• GRNG
• HCCA1
• HCCA2
• YY1AP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.69
transcription factor	0.64
tissue sample	0.63
cell type or tissue	0.61
tissue	0.52

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Yy1-associated Protein 1

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Yy1-associated Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.31   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.31   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0