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Tbio
VCPKMT
Protein-lysine methyltransferase METTL21D

Protein Summary
Description
Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395859
  • ENSP00000379200
  • ENSG00000100483
  • ENST00000395860
  • ENSP00000379201
  • ENST00000491402
  • ENSP00000437113

Symbol
  • C14orf138
  • METTL21D
  • VCP-KMT
  • METTL21D
  • C14orf138
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor
0.75
transcription factor binding site profile
0.73
tissue sample
0.68
cell type or tissue
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
80.2
creatinine measurement
1
1
1
66.8
glomerular filtration rate
1
1
1
66.3
aspartate aminotransferase measurement
1
1
1
66
urate measurement
1
1
1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
80.2
creatinine measurement
1
66.8
glomerular filtration rate
1
66.3
aspartate aminotransferase measurement
1
66
urate measurement
1
65.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
valosin containing protein lysine methyltransferase
VGNC:12417
452896
Mouse
MGI:2684917
207965
Dog
valosin containing protein lysine methyltransferase
VGNC:48245
609034
Horse
valosin containing protein lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:20352]
Cow
valosin containing protein lysine methyltransferase
VGNC:36781
540184
Species
Name
OMA
EggNOG
Inparanoid
Chimp
valosin containing protein lysine methyltransferase
Mouse
Dog
valosin containing protein lysine methyltransferase
Horse
valosin containing protein lysine methyltransferase [Source:HGNC Symbol;Acc:HGNC:20352]
Cow
valosin containing protein lysine methyltransferase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H867-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein methylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Protein methylation
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (39)
1 – 10 of 39
UBXN6
Tbio
Novelty:  0.08383376
p_int:  1
Score:  0.954
Data Source:  BioPlex,STRINGDB
VCP
Tchem
Family:  Enzyme
Novelty:  0.00103317
p_int:  0.991912202
p_ni:  9.5e-8
p_wrong:  0.008087703
Score:  0.996
Data Source:  BioPlex,Reactome,STRINGDB
METTL18
Tdark
Family:  Enzyme
Novelty:  0.3377377
Score:  0.886
Data Source:  STRINGDB
ETFBKMT
Tbio
Family:  Enzyme
Novelty:  0.33247149
Score:  0.849
Data Source:  STRINGDB
EEF1AKMT2
Tbio
Family:  Enzyme
Novelty:  0.13586312
Score:  0.811
Data Source:  STRINGDB
EEF1AKMT1
Tdark
Family:  Enzyme
Novelty:  0.22249584
Score:  0.806
Data Source:  STRINGDB
EEF2KMT
Tdark
Family:  Enzyme
Novelty:  0.33892681
Score:  0.804
Data Source:  STRINGDB
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
Score:  0.783
Data Source:  STRINGDB
METTL22
Tdark
Family:  Enzyme
Novelty:  0.83516873
Score:  0.771
Data Source:  STRINGDB
KIN
Tbio
Novelty:  0.01425955
Score:  0.735
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.25

PubMed score by year
PubTator Score  2.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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