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Tbio
ACAD9
Acyl-CoA dehydrogenase family member 9, mitochondrial

Protein Summary
Description
Required for mitochondrial complex I assembly (PubMed:20816094, PubMed:24158852). Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo (PubMed:20816094, PubMed:24158852). Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0). This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308982
  • ENSP00000312618
  • ENSG00000177646

Symbol
  • NPD002
  • MC1DN20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
disease perturbation
0.79
kinase perturbation
0.76
protein domain
0.73
interacting protein
0.7


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.17   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase family member 9
VGNC:11321
460679
Macaque
acyl-CoA dehydrogenase family member 9
704527
Mouse
MGI:1914272
229211
Rat
RGD:727973
294973
Dog
acyl-CoA dehydrogenase family member 9
476519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA dehydrogenase family member 9
Macaque
acyl-CoA dehydrogenase family member 9
Mouse
Rat
Dog
acyl-CoA dehydrogenase family member 9
Pathways (22)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (140)
1 – 10 of 140
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.999999998
p_ni: 2e-9
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
PDSS2
Tbio
Family: Enzyme
Novelty: 0.02716477
p_int: 0.999998468
p_ni: 0.000001501
p_wrong: 3.1e-8
Score: 0.426
Data Source: BioPlex,STRINGDB
NDUFAF1
Tclin
Novelty: 0.05630549
p_int: 0.999990638
p_ni: 0.000009362
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
COA1
Tbio
Family: Enzyme
Novelty: 0.49194068
p_int: 0.999970654
p_ni: 0.000029266
p_wrong: 8e-8
Data Source: BioPlex
PDSS1
Tbio
Family: Enzyme
Novelty: 0.01542427
p_int: 0.999947956
p_ni: 0.000003933
p_wrong: 0.000048111
Score: 0.831
Data Source: BioPlex,STRINGDB
BPIFA2
Tbio
Novelty: 0.01533858
p_int: 0.999870228
p_ni: 0.000119633
p_wrong: 0.000010139
Data Source: BioPlex
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
p_int: 0.99953058
p_ni: 0.000469415
p_wrong: 5e-9
Score: 0.795
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.997444515
p_ni: 0.002555485
Score: 0.953
Data Source: BioPlex,STRINGDB
TUBB1
Tclin
Novelty: 0.02806117
p_int: 0.995431294
p_ni: 0.004568706
Data Source: BioPlex
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
p_int: 0.994457716
p_ni: 0.005542284
Score: 0.447
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  33.17

PubMed score by year
PubTator Score  23.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer