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Tbio
GEMIN7
Gem-associated protein 7

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270257
  • ENSP00000270257
  • ENSG00000142252
  • ENST00000391951
  • ENSP00000375813
  • ENST00000591607
  • ENSP00000466342
  • ENST00000591747
  • ENSP00000465704

Symbol
  • SIP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
drug perturbation
0.87
transcription factor
0.83
transcription factor binding site profile
0.81
histone modification site profile
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.89   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.89   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
90
1
1
0
5.7
31
family history of Alzheimer’s disease
1
1
0
5.7
31
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
90
0
5.7
31
family history of Alzheimer’s disease
0
5.7
31
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1916981
69731
Rat
RGD:1597035
499391
Dog
gem nuclear organelle associated protein 7
VGNC:41177
100855650
Horse
gem nuclear organelle associated protein 7
VGNC:18306
100065597
Cow
gem nuclear organelle associated protein 7
VGNC:29320
618024
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
gem nuclear organelle associated protein 7
Horse
gem nuclear organelle associated protein 7
Cow
gem nuclear organelle associated protein 7
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Gene Ontology Terms (11)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (84)
1 – 10 of 84
GEMIN8
Tbio
Novelty: 0.19515325
p_int: 0.999999736
p_ni: 2.63e-7
p_wrong: 2e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.999996624
p_ni: 0.000003368
p_wrong: 8e-9
Score: 0.611
Data Source: BioPlex,STRINGDB
GEMIN5
Tbio
Novelty: 0.03683801
p_int: 0.999991422
p_ni: 0.000008578
Score: 0.985
Data Source: BioPlex,STRINGDB
GEMIN6
Tbio
Novelty: 0.02104816
p_int: 0.999989011
p_ni: 0.000010989
Score: 0.999
Data Source: BioPlex,STRINGDB
GEMIN4
Tbio
Novelty: 0.03731756
p_int: 0.999725083
p_ni: 0.000274917
Score: 0.986
Data Source: BioPlex,STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
p_int: 0.996967409
p_ni: 0.000673528
p_wrong: 0.002359064
Score: 0.995
Data Source: BioPlex,STRINGDB
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.994006442
p_ni: 0.005993557
p_wrong: 1e-9
Data Source: BioPlex
STRAP
Tbio
Family: Enzyme
Novelty: 0.0336013
p_int: 0.991963507
p_ni: 0.008036244
p_wrong: 2.49e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
GEMIN2
Tbio
Novelty: 0.02072868
p_int: 0.966781541
p_ni: 0.003094455
p_wrong: 0.030124005
Score: 0.997
Data Source: BioPlex,STRINGDB
LRRC15
Tbio
Novelty: 0.03701624
p_int: 0.929187885
p_ni: 0.070812115
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  17.89

PubMed score by year
PubTator Score  12.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer