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Tbio
PHAX
Phosphorylated adapter RNA export protein

Protein Summary
Description
A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297540
  • ENSP00000297540
  • ENSG00000164902

Symbol
  • RNUXA
  • RNUXA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.79
transcription factor binding site profile
0.74
cellular component
0.67
tissue sample
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
45.7
1
1
0
2.3
33.1
hemoglobin measurement
1
1
1
4.9
1
1
0
1.1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
45.7
0
2.3
33.1
hemoglobin measurement
1
4.9
0
1.1
0.4
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphorylated adaptor for RNA export
VGNC:13564
462034
Macaque
phosphorylated adaptor for RNA export
702980
Mouse
MGI:1891839
56698
Rat
RGD:708448
286917
Dog
phosphorylated adaptor for RNA export
VGNC:51915
479305
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphorylated adaptor for RNA export
Macaque
phosphorylated adaptor for RNA export
Mouse
Rat
Dog
phosphorylated adaptor for RNA export
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H814-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Metabolism of non-coding RNA
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (203)
1 – 10 of 203
SNRPA1
Tbio
Novelty:  0.01232044
p_int:  0.999756743
p_ni:  0.000243257
Score:  0.358
Data Source:  BioPlex,STRINGDB
DDX20
Tbio
Family:  Enzyme
Novelty:  0.01854078
p_int:  0.997926893
p_ni:  0.002073107
Score:  0.975
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.995589079
p_ni:  0.004410921
Score:  0.245
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.991588638
p_ni:  0.008411325
p_wrong:  3.7e-8
Data Source:  BioPlex
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.984146033
p_ni:  0.015853967
Score:  0.549
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.977316996
p_ni:  0.022683004
Score:  0.637
Data Source:  BioPlex,STRINGDB
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.874765006
p_ni:  0.125234994
Score:  0.344
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.815718032
p_ni:  0.184281968
Data Source:  BioPlex
GEMIN7
Tbio
Novelty:  0.04835353
p_int:  0.760932962
p_ni:  0.239067038
Score:  0.946
Data Source:  BioPlex,STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.992
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  23.69

PubMed score by year
PubTator Score  9.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer