Tchem PTGES2 Prostaglandin E synthase 2

Protein Summary

Description

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2). The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• Q9H7Z7
• Q53EW9
• Q5SYV6
• Q96GI0
• Q96GL2

Gene Name

• PTGES2

Ensembl ID

• ENST00000338961
• ENSP00000345341
• ENSG00000148334

Symbol

• C9orf15
• PGES2
• GBF1
• GBF-1
• PGES2
• C9orf15
• mPGES-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
interacting protein	0.86
transcription factor binding site profile	0.85
protein domain	0.73
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Prostaglandin E Synthase 2

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Prostaglandin E Synthase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.2   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 286   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.2   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 133

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0