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Tbio
ZNF703
Zinc finger protein 703

Protein Summary
Description
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331569
  • ENSP00000332325
  • ENSG00000183779

Symbol
  • ZEPPO1
  • ZPO1
  • NLZ1
  • ZPO1
  • ZEPPO1
  • ZNF503L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
disease perturbation
0.79
cell type or tissue
0.78
transcription factor binding site profile
0.77
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.11   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.11   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
9.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
9.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 703
VGNC:3834
464109
Macaque
zinc finger protein 703
698000
Mouse
MGI:2662729
353310
Rat
RGD:1588249
680717
Dog
zinc finger protein 703
VGNC:48802
482855
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 703
Macaque
zinc finger protein 703
Mouse
Rat
Dog
zinc finger protein 703
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H7S9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (59)
1 – 10 of 59
DCAF7
Tbio
Novelty:  0.02609518
p_int:  0.999999106
p_ni:  8.94e-7
Score:  0.641
Data Source:  BioPlex,STRINGDB
HSPBP1
Tbio
Novelty:  0.01176285
p_int:  0.995276741
p_ni:  0.004723258
p_wrong:  1e-9
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.990545157
p_ni:  0.009454812
p_wrong:  3.1e-8
Data Source:  BioPlex
ARHGEF39
Tdark
Novelty:  0.30447134
p_int:  0.981720737
p_ni:  0.018250991
p_wrong:  0.000028272
Data Source:  BioPlex
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.971749236
p_ni:  0.028250764
Data Source:  BioPlex
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.965771542
p_ni:  0.032789125
p_wrong:  0.001439333
Data Source:  BioPlex
TEKT3
Tbio
Novelty:  0.06646482
p_int:  0.940107732
p_ni:  0.059892268
Score:  0.171
Data Source:  BioPlex,STRINGDB
ESRP1
Tbio
Novelty:  0.02035464
p_int:  0.938617008
p_ni:  0.061382697
p_wrong:  2.94e-7
Score:  0.249
Data Source:  BioPlex,STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.931320133
p_ni:  0.068679867
Data Source:  BioPlex
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.902855068
p_ni:  0.097071181
p_wrong:  0.000073751
Data Source:  BioPlex
Publication Statistics
PubMed Score  38.11

PubMed score by year
PubTator Score  15.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer