You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PLEKHG2
Pleckstrin homology domain-containing family G member 2

Protein Summary
Description
May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). The protein encoded by this gene is a RhoGTPase that can activate CDC42 by promoting exchange of GDP for GTP on CDC42. The encoded protein is activated by binding to the beta and gamma subunits of heterotrimeric guanine nucleotide-binding protein. Defects in this gene have been associated with leukodystrophy and acquired microcephaly with or without dystonia. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409797
  • ENSP00000386492
  • ENSG00000090924
  • ENST00000425673
  • ENSP00000392906

Symbol
  • CLG
  • LDAMD
  • ARHGEF42
  • CTB-60E11.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
cell type or tissue
0.79
transcription factor
0.71
cell line
0.64
microRNA
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.57   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.57   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.961
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.958
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.944
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.926
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.916
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.914
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.909
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.908
Data Source:  STRINGDB
RHOT2
Tbio
Family:  Enzyme
Novelty:  0.01712732
Score:  0.907
Data Source:  STRINGDB
RHOBTB2
Tbio
Novelty:  0.00734789
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
77
myeloid white cell count
1
1
1
62.5
leukocyte count
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
77
myeloid white cell count
1
62.5
leukocyte count
1
55.2
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology and RhoGEF domain containing G2
698408
Mouse
MGI:2141874
101497
Rat
RGD:1310112
292750
Dog
pleckstrin homology and RhoGEF domain containing G2
VGNC:44677
484509
Horse
pleckstrin homology and RhoGEF domain containing G2
VGNC:21567
100147191
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology and RhoGEF domain containing G2
Mouse
Rat
Dog
pleckstrin homology and RhoGEF domain containing G2
Horse
pleckstrin homology and RhoGEF domain containing G2
Publication Statistics
PubMed Score 9.57
PubMed score by year
PubTator Score 18.84
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title