You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
VSIR
V-type immunoglobulin domain-containing suppressor of T-cell activation

Protein Summary
Description
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394957
  • ENSP00000378409
  • ENSG00000107738

Symbol
  • C10orf54
  • SISP1
  • VISTA
  • B7H5
  • GI24
  • B7-H5
  • Dies1
  • PD-1H
  • SISP1
  • VISTA
  • PP2135
  • C10orf54
  • DD1alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.61   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.61   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0