You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
VSIR
V-type immunoglobulin domain-containing suppressor of T-cell activation

Protein Summary
Description
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394957
  • ENSP00000378409
  • ENSG00000107738

Symbol
  • C10orf54
  • SISP1
  • VISTA
  • B7H5
  • GI24
  • B7-H5
  • Dies1
  • PD-1H
  • SISP1
  • VISTA
  • PP2135
  • C10orf54
  • DD1alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.93   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.93   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
85.7
leukocyte count
3
2
4
81.6
myeloid white cell count
3
1
3
80.9
monocyte count
2
1
2
77.7
neutrophil count
2
1
2
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
85.7
leukocyte count
4
81.6
myeloid white cell count
3
80.9
monocyte count
2
77.7
neutrophil count
2
74.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
V-set immunoregulatory receptor
VGNC:12272
735593
Macaque
V-set immunoregulatory receptor
709595
Mouse
MGI:1921298
74048
Rat
RGD:1590938
690899
Dog
V-set immunoregulatory receptor
VGNC:51998
106558705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
V-set immunoregulatory receptor
Macaque
V-set immunoregulatory receptor
Mouse
Rat
Dog
V-set immunoregulatory receptor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H7M9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (24)
1 – 10 of 24
PITPNA
Tbio
Novelty:  0.01901136
Score:  0.624
Data Source:  STRINGDB
HAVCR2
Tbio
Novelty:  0.00155885
Score:  0.596
Data Source:  STRINGDB
LAG3
Tbio
Novelty:  0.00187736
Score:  0.591
Data Source:  STRINGDB
BTLA
Tbio
Novelty:  0.00770048
Score:  0.58
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.569
Data Source:  STRINGDB
TRAF1
Tbio
Novelty:  0.00526776
Score:  0.556
Data Source:  STRINGDB
CD274
Tclin
Novelty:  0.00013449
Score:  0.554
Data Source:  STRINGDB
TIGIT
Tbio
Novelty:  0.0064542
Score:  0.533
Data Source:  STRINGDB
VTCN1
Tbio
Novelty:  0.00565174
Score:  0.518
Data Source:  STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.516
Data Source:  STRINGDB
Publication Statistics
PubMed Score  42.93

PubMed score by year
PubTator Score  104.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: