Tbio VSIR V-type immunoglobulin domain-containing suppressor of T-cell activation

Protein Summary

Description

Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).

Uniprot Accession IDs

• Q9H7M9
• A1L0X9
• A4ZYV1
• A8MVH5
• Q6UXF3
• Q8WUG3
• Q8WYZ8

Gene Name

• VSIR

Ensembl ID

• ENST00000394957
• ENSP00000378409
• ENSG00000107738

Symbol

• C10orf54
• SISP1
• VISTA
• B7H5
• GI24
• B7-H5
• Dies1
• PD-1H
• SISP1
• VISTA
• PP2135
• C10orf54
• DD1alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.61   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 293   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.61   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0